LINC01227

Summary

LINC01227 (long intergenic non-protein coding RNA 1227, HGNC:49680) is a long non-coding RNA gene on chromosome 16q23.2.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:49680
Approved symbol	LINC01227
Name	long intergenic non-protein coding RNA 1227
Location	16q23.2
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000260737
Ensembl biotype	lncRNA
Entrez	101928276
RNAcentral	URS000075CD04 — lncRNA, 847 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 16 — 16 lncRNA

ENST00000561634, ENST00000561719, ENST00000562002, ENST00000565215, ENST00000567317, ENST00000652792, ENST00000654679, ENST00000654863, ENST00000656480, ENST00000660108, ENST00000662243, ENST00000663234, ENST00000663414, ENST00000664145, ENST00000666768, ENST00000670104

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000561634 — 3 exons

Exon	Start	End
ENSE00002589924	80567555	80567759
ENSE00002595246	80567948	80568113
ENSE00002614816	80568816	80569687

Expression profiles

Bgee: expression breadth broad, 75 present calls, max score 96.84.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.0554 / max 16.6901, expressed in 16 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
158246	0.0313	12
158245	0.0241	4

Top tissues by expression

189 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sperm	CL:0000019	96.84	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	85.19	gold quality
left testis	UBERON:0004533	81.20	gold quality
right testis	UBERON:0004534	79.22	gold quality
right uterine tube	UBERON:0001302	78.97	gold quality
testis	UBERON:0000473	78.32	gold quality
sural nerve	UBERON:0015488	73.37	silver quality
epithelial cell of pancreas	CL:0000083	66.63	gold quality
bone marrow cell	CL:0002092	65.98	silver quality
upper arm skin	UBERON:0004263	65.58	gold quality
tibial nerve	UBERON:0001323	63.29	gold quality
islet of Langerhans	UBERON:0000006	56.73	gold quality
cardiac muscle of right atrium	UBERON:0003379	54.34	gold quality
left ventricle myocardium	UBERON:0006566	54.23	gold quality
nasal cavity epithelium	UBERON:0005384	54.07	gold quality
kidney epithelium	UBERON:0004819	53.93	gold quality
adult organism	UBERON:0007023	53.64	gold quality
buccal mucosa cell	CL:0002336	53.06	gold quality
endocervix	UBERON:0000458	52.90	gold quality
monocyte	CL:0000576	52.85	silver quality
lateral globus pallidus	UBERON:0002476	52.30	gold quality
deltoid	UBERON:0001476	51.67	gold quality
endothelial cell	CL:0000115	51.63	gold quality
quadriceps femoris	UBERON:0001377	51.39	gold quality
pancreatic ductal cell	CL:0002079	50.39	silver quality
myocardium	UBERON:0002349	50.25	gold quality
pancreas	UBERON:0001264	50.07	silver quality
vastus lateralis	UBERON:0001379	50.03	gold quality
muscle tissue	UBERON:0002385	49.05	gold quality
metanephros	UBERON:0000081	48.53	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	2.60

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.