LINC01228

Summary

LINC01228 (long intergenic non-protein coding RNA 1228, HGNC:49681) is a long non-coding RNA gene on chromosome 16q23.2.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:49681
Approved symbol	LINC01228
Name	long intergenic non-protein coding RNA 1228
Location	16q23.2
Locus type	RNA, long non-coding
Status	Approved
Aliases	lincRNA-DYNLRB2-2
Ensembl gene	ENSG00000261082
Ensembl biotype	lncRNA
Entrez	104266962
RNAcentral	URS00021231F7 — lncRNA, 838 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 2 — 2 lncRNA

ENST00000567966, ENST00000766963

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000567966 — 2 exons

Exon	Start	End
ENSE00004126105	79797826	79798509
ENSE00004126107	79826988	79827185

Expression profiles

Bgee: expression breadth broad, 86 present calls, max score 80.30.

Top tissues by expression

86 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	80.30	silver quality
ganglionic eminence	UBERON:0004023	61.79	gold quality
cortical plate	UBERON:0005343	61.54	gold quality
monocyte	CL:0000576	59.20	gold quality
skeletal muscle tissue	UBERON:0001134	57.36	gold quality
gall bladder	UBERON:0002110	56.95	gold quality
left uterine tube	UBERON:0001303	56.09	gold quality
prefrontal cortex	UBERON:0000451	53.49	gold quality
placenta	UBERON:0001987	53.43	gold quality
urinary bladder	UBERON:0001255	52.37	gold quality
right lobe of thyroid gland	UBERON:0001119	52.06	gold quality
right adrenal gland cortex	UBERON:0035827	51.51	gold quality
bone marrow	UBERON:0002371	51.04	silver quality
blood	UBERON:0000178	50.06	silver quality
liver	UBERON:0002107	49.97	silver quality
smooth muscle tissue	UBERON:0001135	49.64	gold quality
right lobe of liver	UBERON:0001114	49.25	silver quality
endometrium	UBERON:0001295	48.83	gold quality
muscle of leg	UBERON:0001383	48.59	gold quality
gastrocnemius	UBERON:0001388	47.91	gold quality
body of uterus	UBERON:0009853	47.44	gold quality
vagina	UBERON:0000996	47.36	gold quality
primary visual cortex	UBERON:0002436	46.68	silver quality
endocervix	UBERON:0000458	46.14	gold quality
myometrium	UBERON:0001296	45.32	gold quality
heart left ventricle	UBERON:0002084	44.94	gold quality
islet of Langerhans	UBERON:0000006	44.89	silver quality
tonsil	UBERON:0002372	44.49	gold quality
right adrenal gland	UBERON:0001233	44.08	gold quality
putamen	UBERON:0001874	44.03	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.80

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• Oxidized-LDL significantly induces lincRNA-DYNLRB2-2 expression, which promotes ABCA1-mediated cholesterol efflux and inhibits inflammation through GPR119 in THP-1 cells. (PMID:24493833)
• Results show that LincRNA DYN-LRB2-2 upregulates cholesterol efflux by decreasing TLR2 expression in macrophages. (PMID:28815701)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.