LINC01232

Summary

LINC01232 (long intergenic non-protein coding RNA 1232, HGNC:49755) is a long non-coding RNA gene on chromosome 13q32.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:49755
Approved symbol	LINC01232
Name	long intergenic non-protein coding RNA 1232
Location	13q32.3
Locus type	RNA, long non-coding
Status	Approved
Aliases	FLJ41590, TCONS_00021520
Ensembl gene	ENSG00000280734
Ensembl biotype	lncRNA
Entrez	102725509
RNAcentral	URS000075E1B1 — lncRNA, 1817 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 18 — 17 lncRNA, 1 retained_intron

ENST00000366259, ENST00000625254, ENST00000625287, ENST00000625369, ENST00000626729, ENST00000630421, ENST00000656995, ENST00000715701, ENST00000715702, ENST00000745985, ENST00000745986, ENST00000745987, ENST00000745988, ENST00000745989, ENST00000745990, ENST00000745991, ENST00000745992, ENST00000745993

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000366259 — 2 exons

Exon	Start	End
ENSE00004086438	99499609	99499940
ENSE00004086442	99500395	99501313

Expression profiles

Bgee: expression breadth ubiquitous, 134 present calls, max score 80.97.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.0765 / max 9.9239, expressed in 32 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
138022	0.0765	32

Top tissues by expression

134 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	80.97	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	79.51	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	78.66	gold quality
sural nerve	UBERON:0015488	78.26	gold quality
liver	UBERON:0002107	78.14	gold quality
right lobe of liver	UBERON:0001114	77.77	gold quality
right testis	UBERON:0004534	76.53	gold quality
leukocyte	CL:0000738	75.88	gold quality
testis	UBERON:0000473	75.82	gold quality
monocyte	CL:0000576	75.78	gold quality
left testis	UBERON:0004533	75.23	gold quality
granulocyte	CL:0000094	75.03	gold quality
substantia nigra	UBERON:0002038	74.65	gold quality
lymph node	UBERON:0000029	74.26	gold quality
duodenum	UBERON:0002114	73.37	gold quality
corpus callosum	UBERON:0002336	73.16	gold quality
spleen	UBERON:0002106	72.73	gold quality
blood	UBERON:0000178	72.64	gold quality
Ammon’s horn	UBERON:0001954	71.95	gold quality
bone marrow cell	CL:0002092	71.49	silver quality
vermiform appendix	UBERON:0001154	71.41	gold quality
amygdala	UBERON:0001876	71.40	gold quality
temporal lobe	UBERON:0001871	71.25	gold quality
placenta	UBERON:0001987	71.16	gold quality
right adrenal gland cortex	UBERON:0035827	69.87	gold quality
putamen	UBERON:0001874	69.86	gold quality
hypothalamus	UBERON:0001898	69.72	gold quality
adrenal tissue	UBERON:0018303	69.37	gold quality
esophagus mucosa	UBERON:0002469	69.27	gold quality
rectum	UBERON:0001052	69.19	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	4.65

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 8)

• Linc01232 promotes the metastasis of pancreatic cancer by suppressing the ubiquitin-mediated degradation of HNRNPA2B1 and activating the A-Raf-induced MAPK/ERK signaling pathway. (PMID:32814086)
• Long intergenic noncoding RNA LINC01232 contributes to esophageal squamous cell carcinoma progression by sequestering microRNA6543p and consequently promoting hepatomaderived growth factor expression. (PMID:33125097)
• LINC01232 Sponges Multiple miRNAs and Its Clinical Significance in Pancreatic Adenocarcinoma Diagnosis and Prognosis. (PMID:33506742)
• Elevated LINC01232 is associated with poor prognosis and HBV infection in hepatocellular carcinoma patients and contributes to tumor progression in vitro. (PMID:34583064)
• FOXP3 activated-LINC01232 accelerates the stemness of non-small cell lung carcinoma by activating TGF-beta signaling pathway and recruiting IGF2BP2 to stabilize TGFBR1. (PMID:35026283)
• LINC01232 promotes lung squamous cell carcinoma progression through modulating miR-181a-5p/SMAD2 axis. (PMID:36543302)
• Tumor-Associated Macrophage-Derived Exosomal LINC01232 Induces the Immune Escape in Glioma by Decreasing Surface MHC-I Expression. (PMID:37097629)
• LINC01232 targeting miR-1250-3p/MSH2 axis attenuates mesangial cell proliferation and fibrosis in diabetic nephropathy. (PMID:37642881)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.