LINC01234

Summary

LINC01234 (long intergenic non-protein coding RNA 1234, HGNC:49757) is a long non-coding RNA gene on chromosome 12q24.13.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:49757
Approved symbol	LINC01234
Name	long intergenic non-protein coding RNA 1234
Location	12q24.13
Locus type	RNA, long non-coding
Status	Approved
Aliases	onco-lncRNA-32, MBOP
Ensembl gene	ENSG00000249550
Ensembl biotype	lncRNA
Entrez	100506465
RNAcentral	URS0000759D3F — lncRNA, 2222 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 25 — 25 lncRNA

ENST00000510694, ENST00000547963, ENST00000550223, ENST00000550905, ENST00000551982, ENST00000653736, ENST00000654810, ENST00000655514, ENST00000657279, ENST00000659032, ENST00000661033, ENST00000661760, ENST00000662051, ENST00000662465, ENST00000663699, ENST00000669504, ENST00000669851, ENST00000762236, ENST00000762237, ENST00000762238, ENST00000762239, ENST00000762240, ENST00000762241, ENST00000762242, ENST00000841166

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000510694 — 4 exons

Exon	Start	End
ENSE00002038966	113767075	113767208
ENSE00002057039	113753431	113753563
ENSE00002086459	113751014	113752188
ENSE00003858678	113773615	113773708

Expression profiles

Bgee: expression breadth ubiquitous, 156 present calls, max score 81.60.

FANTOM5 (CAGE): breadth broad, TPM avg 1.1964 / max 83.2668, expressed in 344 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
133370	0.8171	278
133371	0.3794	192

Top tissues by expression

234 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	81.60	gold quality
bone marrow cell	CL:0002092	79.91	gold quality
buccal mucosa cell	CL:0002336	78.69	silver quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	77.05	gold quality
prefrontal cortex	UBERON:0000451	72.19	gold quality
Brodmann (1909) area 9	UBERON:0013540	71.77	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	70.58	gold quality
anterior cingulate cortex	UBERON:0009835	69.81	gold quality
right frontal lobe	UBERON:0002810	69.72	gold quality
sural nerve	UBERON:0015488	68.86	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	68.13	gold quality
amygdala	UBERON:0001876	68.09	gold quality
spinal cord	UBERON:0002240	67.84	gold quality
hypothalamus	UBERON:0001898	67.80	gold quality
neocortex	UBERON:0001950	67.27	gold quality
frontal cortex	UBERON:0001870	66.89	gold quality
cortical plate	UBERON:0005343	65.22	gold quality
cerebral cortex	UBERON:0000956	64.21	gold quality
primary visual cortex	UBERON:0002436	64.11	gold quality
substantia nigra	UBERON:0002038	62.91	gold quality
apex of heart	UBERON:0002098	61.20	gold quality
lateral nuclear group of thalamus	UBERON:0002736	60.73	silver quality
forebrain	UBERON:0001890	60.59	gold quality
midbrain	UBERON:0001891	60.27	gold quality
ventricular zone	UBERON:0003053	60.27	gold quality
ganglionic eminence	UBERON:0004023	60.12	gold quality
brain	UBERON:0000955	59.83	gold quality
middle temporal gyrus	UBERON:0002771	59.70	gold quality
temporal lobe	UBERON:0001871	59.49	gold quality
nucleus accumbens	UBERON:0001882	59.48	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	4.24

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 14)

• We further demonstrated the suppressive function of lncRNA#32 in hepatitis B virus and hepatitis C virus infection. lncRNA#32 bound to activating transcription factor 2 (ATF2) and regulated ISG expression. Our results reveal a role for lncRNA#32 in host antiviral responses. (PMID:27582466)
• we identified a novel gastric cancer-associated lncRNA-LINC01234 and first uncover that LINC01234 is an oncogenic lncRNA that promotes cell proliferation and inhibits cell apoptosis through miR-204-5p-CBFB axis in human gastric cancer. (PMID:29386218)
• Mechanistic investigation elucidated that LINC01234 inhibited the activity of miR-637 to increase the expression of NUPR1; this contributed to malignant behaviors of oral squamous cell carcinoma cells. (PMID:31590125)
• Long noncoding RNA LINC01234 promoted cell proliferation and invasion via miR-1284/TRAF6 axis in colorectal cancer. (PMID:31904146)
• Up-regulated LINC01234 promotes non-small-cell lung cancer cell metastasis by activating VAV3 and repressing BTG2 expression. (PMID:31959200)
• Function and regulation annotation of up-regulated long non-coding RNA LINC01234 in gastric cancer. (PMID:32011780)
• Long noncoding RNA LINC01234 silencing exerts an anti-oncogenic effect in esophageal cancer cells through microRNA-193a-5p-mediated CCNE1 downregulation. (PMID:32130660)
• Integrative Analysis of NSCLC Identifies LINC01234 as an Oncogenic lncRNA that Interacts with HNRNPA2B1 and Regulates miR-106b Biogenesis. (PMID:32246902)
• LINC01234 aggravates cell growth and migration of triple-negative breast cancer by activating the Wnt pathway. (PMID:34173712)
• The Role of the LINC01234/miR-433-3p/GRB2 ceRNA Network in NSCLC Cell Malignant Proliferation. (PMID:35747966)
• LINC01234 Accelerates the Progression of Breast Cancer via the miR-525-5p/Cold Shock Domain-Containing E1 Axis. (PMID:35923244)
• Oncogenic roles of LINC01234 in various forms of human cancer. (PMID:36030582)
• Silencing LINC01234 represses pancreatic cancer progression by inhibiting the malignant phenotypes of pancreatic cancer cells. (PMID:36343541)
• LINC01234 promoted malignant behaviors of breast cancer cells via hsa-miR-30c-2-3p/CCT4/mTOR signaling pathway. (PMID:38216268)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.