LINC01270

Summary

LINC01270 (long intergenic non-protein coding RNA 1270, HGNC:27658) is a long non-coding RNA gene on chromosome 20q13.13.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:27658
Approved symbol	LINC01270
Name	long intergenic non-protein coding RNA 1270
Location	20q13.13
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000203999
Ensembl biotype	lncRNA
Entrez	284751
RNAcentral	URS000075EEAB — lncRNA, 2278 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 17 — 17 lncRNA

ENST00000371639, ENST00000457853, ENST00000653657, ENST00000653865, ENST00000653970, ENST00000655316, ENST00000655675, ENST00000655925, ENST00000661795, ENST00000662382, ENST00000663616, ENST00000664104, ENST00000669676, ENST00000671482, ENST00000701020, ENST00000718356, ENST00000718357

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000371639 — 5 exons

Exon	Start	End
ENSE00001455726	50298156	50298413
ENSE00001455727	50292720	50292830
ENSE00001542574	50312352	50312430
ENSE00001542575	50311805	50312014
ENSE00003884961	50313300	50314923

Expression profiles

Bgee: expression breadth ubiquitous, 151 present calls, max score 79.10.

FANTOM5 (CAGE): breadth broad, TPM avg 1.3574 / max 94.0697, expressed in 586 samples.

FANTOM5 promoters (5 alternative TSS)

Promoter ID	TPM avg	Samples expressed
185237	0.5776	321
185243	0.2945	47
185238	0.2135	81
185240	0.1779	39
185242	0.0939	31

Top tissues by expression

239 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right lobe of liver	UBERON:0001114	79.10	gold quality
blood	UBERON:0000178	76.74	gold quality
right adrenal gland	UBERON:0001233	76.17	gold quality
right adrenal gland cortex	UBERON:0035827	75.84	gold quality
left adrenal gland	UBERON:0001234	74.10	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	73.82	gold quality
left adrenal gland cortex	UBERON:0035825	73.39	gold quality
spleen	UBERON:0002106	72.06	gold quality
adrenal cortex	UBERON:0001235	71.57	gold quality
stromal cell of endometrium	CL:0002255	70.95	gold quality
adrenal gland	UBERON:0002369	70.72	gold quality
granulocyte	CL:0000094	69.23	gold quality
vermiform appendix	UBERON:0001154	68.98	gold quality
hindlimb stylopod muscle	UBERON:0004252	68.27	gold quality
muscle of leg	UBERON:0001383	67.87	gold quality
gastrocnemius	UBERON:0001388	67.24	gold quality
right lobe of thyroid gland	UBERON:0001119	67.17	gold quality
liver	UBERON:0002107	67.15	gold quality
right lung	UBERON:0002167	66.58	gold quality
leukocyte	CL:0000738	66.19	gold quality
left lobe of thyroid gland	UBERON:0001120	66.03	gold quality
monocyte	CL:0000576	65.92	gold quality
thyroid gland	UBERON:0002046	64.45	gold quality
upper lobe of left lung	UBERON:0008952	63.96	gold quality
apex of heart	UBERON:0002098	63.93	gold quality
left uterine tube	UBERON:0001303	63.29	gold quality
upper lobe of lung	UBERON:0008948	63.11	gold quality
smooth muscle tissue	UBERON:0001135	62.77	gold quality
caecum	UBERON:0001153	62.77	gold quality
right atrium auricular region	UBERON:0006631	62.69	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.60

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 4)

• Silencing of long non-coding RNA LINC01270 inhibits esophageal cancer progression and enhances chemosensitivity to 5-fluorouracil by mediating GSTP1methylation. (PMID:33199829)
• LncRNA LINC01270 aggravates the progression of gastric cancer through modulation of miR-326/EFNA3 axis. (PMID:35345980)
• Epigenetic regulation of LINC01270 in breast cancer progression by mediating LAMA2 promoter methylation and MAPK signaling pathway. (PMID:36241925)
• Abnormal expression of long non-coding RNA LINC01270 in glioma and its correlation with X-ray computed tomography signs. (PMID:38587325)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.