LINC01278

Summary

LINC01278 (long intergenic non-protein coding RNA 1278, HGNC:28090) is a long non-coding RNA gene on chromosome Xq11.1.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:28090
Approved symbol	LINC01278
Name	long intergenic non-protein coding RNA 1278
Location	Xq11.1
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000235437
Ensembl biotype	lncRNA
Entrez	92249
RNAcentral	URS0000CCE138 — lncRNA, 3006 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 53 — 52 lncRNA, 1 retained_intron

ENST00000433061, ENST00000608623, ENST00000608788, ENST00000609143, ENST00000609401, ENST00000610088, ENST00000610234, ENST00000653861, ENST00000654240, ENST00000654366, ENST00000654880, ENST00000656953, ENST00000656972, ENST00000659087, ENST00000659222, ENST00000659363, ENST00000659374, ENST00000661141, ENST00000662156, ENST00000662689, ENST00000662779, ENST00000664128, ENST00000664356, ENST00000665386, ENST00000665831, ENST00000665925, ENST00000666216, ENST00000666437, ENST00000666891, ENST00000667050, ENST00000669201, ENST00000669422, ENST00000669572, ENST00000670203, ENST00000670242, ENST00000670248, ENST00000670731, ENST00000671033, ENST00000671338, ENST00000701823, ENST00000761744, ENST00000761745, ENST00000761746, ENST00000761747, ENST00000761748, ENST00000761749, ENST00000761750, ENST00000761751, ENST00000761752, ENST00000761753, ENST00000761754, ENST00000761755, ENST00000761756

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000433061 — 3 exons

Exon	Start	End
ENSE00001772781	63560832	63561049
ENSE00001778820	63509942	63510079
ENSE00002402662	63516910	63517082

Expression profiles

Bgee: expression breadth ubiquitous, 223 present calls, max score 94.73.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 21.1749 / max 434.1932, expressed in 1762 samples.

FANTOM5 promoters (5 alternative TSS)

Promoter ID	TPM avg	Samples expressed
199452	18.0539	1758
199445	1.8756	674
199444	0.5980	294
199450	0.3331	175
199451	0.3143	181

Top tissues by expression

273 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
popliteal artery	UBERON:0002250	94.73	gold quality
tibial artery	UBERON:0007610	94.72	gold quality
right coronary artery	UBERON:0001625	93.83	gold quality
aorta	UBERON:0000947	93.37	gold quality
lower esophagus muscularis layer	UBERON:0035833	92.87	gold quality
lower esophagus	UBERON:0013473	92.85	gold quality
muscle layer of sigmoid colon	UBERON:0035805	92.80	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	92.57	gold quality
adenohypophysis	UBERON:0002196	92.07	gold quality
left coronary artery	UBERON:0001626	92.03	gold quality
ascending aorta	UBERON:0001496	91.72	gold quality
thoracic aorta	UBERON:0001515	91.71	gold quality
right uterine tube	UBERON:0001302	91.59	gold quality
coronary artery	UBERON:0001621	91.39	gold quality
body of uterus	UBERON:0009853	91.36	gold quality
pituitary gland	UBERON:0000007	91.22	gold quality
left lobe of thyroid gland	UBERON:0001120	90.47	gold quality
right atrium auricular region	UBERON:0006631	90.33	gold quality
descending thoracic aorta	UBERON:0002345	90.26	gold quality
left uterine tube	UBERON:0001303	90.21	gold quality
right lobe of thyroid gland	UBERON:0001119	89.97	gold quality
thyroid gland	UBERON:0002046	89.77	gold quality
colonic epithelium	UBERON:0000397	89.51	gold quality
left ovary	UBERON:0002119	89.36	gold quality
right ovary	UBERON:0002118	89.08	gold quality
cardiac atrium	UBERON:0002081	88.83	gold quality
prostate gland	UBERON:0002367	88.81	gold quality
minor salivary gland	UBERON:0001830	88.78	gold quality
mucosa of stomach	UBERON:0001199	88.69	gold quality
endocervix	UBERON:0000458	88.53	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 4)

• LncRNA LINC01278 accelerates colorectal cancer progression via miR-134-5p/KDM2A axis. (PMID:33155208)
• LINC01278 Induces Autophagy to Inhibit Tumour Progression by Suppressing the mTOR Signalling Pathway. (PMID:36713034)
• Signal Transducer and Activator of Transcription 4-Induced Up-Regulated LINC01278 Enhances Proliferation and Invasion of Non-Small Cell Lung Cancer Cells via the MicroRNA-877-5p/Activating Transcription Factor 4 Axis. (PMID:38466361)
• LncRNA LINC01278 Regulates the Prognosis and Related Mechanisms of Gastric Cancer by Targeting miR-129-5p. (PMID:39016140)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.