LINC01287

Summary

LINC01287 (long intergenic non-protein coding RNA 1287, HGNC:50351) is a long non-coding RNA gene on chromosome 7q36.2.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50351
Approved symbol	LINC01287
Name	long intergenic non-protein coding RNA 1287
Location	7q36.2
Locus type	RNA, long non-coding
Status	Approved
Aliases	TCONS_l2_00027522
Ensembl gene	ENSG00000234722
Ensembl biotype	lncRNA
Entrez	103724390
RNAcentral	URS00007E40BE — lncRNA, 1008 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 41 — 41 lncRNA

ENST00000416982, ENST00000453187, ENST00000454441, ENST00000647863, ENST00000653989, ENST00000655449, ENST00000657245, ENST00000658753, ENST00000658825, ENST00000659532, ENST00000660414, ENST00000661082, ENST00000661522, ENST00000662256, ENST00000662626, ENST00000662979, ENST00000663745, ENST00000663904, ENST00000664034, ENST00000664249, ENST00000665005, ENST00000665256, ENST00000665909, ENST00000666243, ENST00000667969, ENST00000668024, ENST00000669043, ENST00000669107, ENST00000669109, ENST00000669159, ENST00000669370, ENST00000669410, ENST00000669806, ENST00000669818, ENST00000670171, ENST00000670343, ENST00000670362, ENST00000670691, ENST00000671302, ENST00000774315, ENST00000774316

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000416982 — 2 exons

Exon	Start	End
ENSE00001637005	153411582	153413963
ENSE00001767854	153411234	153411475

Expression profiles

Bgee: expression breadth ubiquitous, 134 present calls, max score 82.82.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.3243 / max 28.7448, expressed in 59 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
205007	0.3243	59

Top tissues by expression

134 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	82.82	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	81.60	gold quality
sural nerve	UBERON:0015488	78.55	gold quality
cortical plate	UBERON:0005343	74.74	gold quality
ganglionic eminence	UBERON:0004023	72.63	gold quality
skin of abdomen	UBERON:0001416	71.82	gold quality
zone of skin	UBERON:0000014	70.66	gold quality
skin of leg	UBERON:0001511	69.88	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	69.23	gold quality
colonic epithelium	UBERON:0000397	68.56	silver quality
bone marrow cell	CL:0002092	68.13	silver quality
cerebellum	UBERON:0002037	67.60	gold quality
primary visual cortex	UBERON:0002436	67.60	gold quality
cerebellar cortex	UBERON:0002129	67.52	gold quality
minor salivary gland	UBERON:0001830	67.48	gold quality
right hemisphere of cerebellum	UBERON:0014890	67.44	gold quality
substantia nigra	UBERON:0002038	67.36	gold quality
cerebellar hemisphere	UBERON:0002245	67.36	gold quality
skeletal muscle tissue	UBERON:0001134	67.32	gold quality
saliva-secreting gland	UBERON:0001044	67.14	gold quality
muscle of leg	UBERON:0001383	67.13	gold quality
gastrocnemius	UBERON:0001388	67.02	gold quality
lymph node	UBERON:0000029	67.01	gold quality
endometrium	UBERON:0001295	66.71	gold quality
vagina	UBERON:0000996	66.50	gold quality
ectocervix	UBERON:0012249	65.97	gold quality
granulocyte	CL:0000094	65.96	gold quality
temporal lobe	UBERON:0001871	65.95	gold quality
amygdala	UBERON:0001876	65.86	gold quality
Ammon’s horn	UBERON:0001954	65.83	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	4.07

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 6)

• LINC01287 exerted as a ceRNA and negatively regulated miR-298 expression. MYB was identified as a downstream target of miR-298. The miR-298/MYB axis mediated LINC01287’s effect on hepatocellular carcinoma (HCC) (PMID:30133116)
• Long non-coding RNA LINC01287 promotes breast cancer cells proliferation and metastasis by activating Wnt/ss-catenin signaling. (PMID:31173295)
• Proliferation and migration of hepatocellular carcinoma are accelerated by LINC01287 via the miR-559/TCF12 axis. (PMID:32572916)
• Long noncoding RNA LINC01287 promotes proliferation and inhibits apoptosis of lung adenocarcinoma cells via the miR-3529-5p/RNASEH2A axis under the competitive endogenous RNA pattern. (PMID:34254728)
• Oncogenic Long Noncoding RNA Linc01287 Promotes IGF1R Expression by Sponging miR-98 in Breast Cancer. (PMID:35695608)
• Long intergenic noncoding RNA LINC01287 drives the progression of cervical cancer via regulating miR-513a-5p/SERP1. (PMID:35895184)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.