LINC01291

Summary

LINC01291 (long intergenic non-protein coding RNA 1291, HGNC:50358) is a long non-coding RNA gene on chromosome 2p12.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50358
Approved symbol	LINC01291
Name	long intergenic non-protein coding RNA 1291
Location	2p12
Locus type	RNA, long non-coding
Status	Approved
Aliases	TCONS_00002938, AC104135.4
Ensembl gene	ENSG00000204792
Ensembl biotype	lncRNA
Entrez	102724515
RNAcentral	URS0002853A71 — lncRNA, 5442 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 11 — 11 lncRNA

ENST00000377469, ENST00000418204, ENST00000435984, ENST00000453951, ENST00000717897, ENST00000840152, ENST00000840153, ENST00000840154, ENST00000840155, ENST00000840156, ENST00000840157

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000377469 — 2 exons

Exon	Start	End
ENSE00001474021	74932661	74933024
ENSE00001474023	74928239	74931536

Expression profiles

Bgee: expression breadth ubiquitous, 132 present calls, max score 82.35.

FANTOM5 (CAGE): breadth broad, TPM avg 1.7863 / max 47.9736, expressed in 205 samples.

FANTOM5 promoters (5 alternative TSS)

Promoter ID	TPM avg	Samples expressed
21080	1.6089	139
21082	0.0748	38
21081	0.0663	26
21084	0.0348	5
21083	0.0015	1

Top tissues by expression

132 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	82.35	gold quality
monocyte	CL:0000576	75.86	gold quality
leukocyte	CL:0000738	74.86	gold quality
lymph node	UBERON:0000029	74.85	gold quality
smooth muscle tissue	UBERON:0001135	73.27	gold quality
fallopian tube	UBERON:0003889	73.12	gold quality
granulocyte	CL:0000094	73.06	gold quality
right uterine tube	UBERON:0001302	72.84	gold quality
bone marrow cell	CL:0002092	72.36	silver quality
gall bladder	UBERON:0002110	72.34	gold quality
right ovary	UBERON:0002118	71.93	gold quality
ovary	UBERON:0000992	71.92	gold quality
right coronary artery	UBERON:0001625	71.86	gold quality
ventricular zone	UBERON:0003053	71.75	gold quality
left ovary	UBERON:0002119	71.59	gold quality
calcaneal tendon	UBERON:0003701	71.50	gold quality
tonsil	UBERON:0002372	70.48	gold quality
left adrenal gland cortex	UBERON:0035825	70.47	gold quality
left adrenal gland	UBERON:0001234	70.36	gold quality
endocervix	UBERON:0000458	70.10	gold quality
left uterine tube	UBERON:0001303	70.02	gold quality
colonic epithelium	UBERON:0000397	69.41	silver quality
adrenal gland	UBERON:0002369	68.64	gold quality
spleen	UBERON:0002106	68.63	gold quality
body of uterus	UBERON:0009853	68.51	gold quality
islet of Langerhans	UBERON:0000006	68.47	gold quality
uterine cervix	UBERON:0000002	68.31	gold quality
metanephros cortex	UBERON:0010533	68.27	gold quality
right adrenal gland	UBERON:0001233	68.22	gold quality
popliteal artery	UBERON:0002250	67.75	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	3.20

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• Long noncoding RNA LINC01291 promotes the aggressive properties of melanoma by functioning as a competing endogenous RNA for microRNA-625-5p and subsequently increasing IGF-1R expression. (PMID:33674778)
• LINC01291 promotes hepatocellular carcinoma development by targeting the miR-186-5p/OXSR1 axis. (PMID:34665488)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.