LINC01305

Summary

LINC01305 (long intergenic non-protein coding RNA 1305, HGNC:27690) is a long non-coding RNA gene on chromosome 2q31.1.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:27690
Approved symbol	LINC01305
Name	long intergenic non-protein coding RNA 1305
Location	2q31.1
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000231453
Ensembl biotype	lncRNA
Entrez	285084
RNAcentral	URS000075E2AF — lncRNA, 3140 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 12 — 12 lncRNA

ENST00000420866, ENST00000436820, ENST00000823786, ENST00000823787, ENST00000823788, ENST00000823789, ENST00000823790, ENST00000823791, ENST00000823792, ENST00000823793, ENST00000823794, ENST00000823795

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000420866 — 3 exons

Exon	Start	End
ENSE00001733375	174326027	174327410
ENSE00001772406	174328457	174328836
ENSE00001803129	174329285	174330643

Expression profiles

Bgee: expression breadth broad, 95 present calls, max score 93.92.

Top tissues by expression

191 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
buccal mucosa cell	CL:0002336	93.92	gold quality
stromal cell of endometrium	CL:0002255	69.85	gold quality
skin of hip	UBERON:0001554	69.15	gold quality
ganglionic eminence	UBERON:0004023	64.90	gold quality
ventricular zone	UBERON:0003053	63.38	gold quality
putamen	UBERON:0001874	62.52	gold quality
upper leg skin	UBERON:0004262	61.85	gold quality
skin of abdomen	UBERON:0001416	60.12	gold quality
cortical plate	UBERON:0005343	59.95	gold quality
right uterine tube	UBERON:0001302	59.93	gold quality
caudate nucleus	UBERON:0001873	59.31	gold quality
prefrontal cortex	UBERON:0000451	56.23	gold quality
nucleus accumbens	UBERON:0001882	55.69	gold quality
monocyte	CL:0000576	55.13	gold quality
zone of skin	UBERON:0000014	55.03	gold quality
minor salivary gland	UBERON:0001830	53.26	gold quality
anterior cingulate cortex	UBERON:0009835	52.73	gold quality
mouth mucosa	UBERON:0003729	51.79	gold quality
saliva-secreting gland	UBERON:0001044	51.21	gold quality
neocortex	UBERON:0001950	51.18	gold quality
forebrain	UBERON:0001890	50.83	gold quality
frontal cortex	UBERON:0001870	50.74	gold quality
fallopian tube	UBERON:0003889	50.33	gold quality
brain	UBERON:0000955	50.32	gold quality
skin of leg	UBERON:0001511	50.27	gold quality
right hemisphere of cerebellum	UBERON:0014890	50.12	gold quality
muscle of leg	UBERON:0001383	50.10	silver quality
amygdala	UBERON:0001876	50.07	gold quality
adipose tissue	UBERON:0001013	49.96	gold quality
Brodmann (1909) area 9	UBERON:0013540	49.76	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.46

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 3)

• Silencing LncRNA LINC01305 inhibits epithelial mesenchymal transition in lung cancer cells by regulating TNXB-mediated PI3K/Akt signaling pathway. (PMID:32549529)
• LncRNA LINC01305 promotes cervical cancer progression through KHSRP and exosome-mediated transfer. (PMID:33638945)
• linc01305 promotes metastasis and proliferation of esophageal squamous cell carcinoma through interacting with IGF2BP2 and IGF2BP3 to stabilize HTR3A mRNA. (PMID:34022433)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.