LINC01315

Summary

LINC01315 (long intergenic non-protein coding RNA 1315, HGNC:50513) is a long non-coding RNA gene on chromosome 22q13.2.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50513
Approved symbol	LINC01315
Name	long intergenic non-protein coding RNA 1315
Location	22q13.2
Locus type	RNA, long non-coding
Status	Approved
Aliases	lnc-C22orf32-1, C22orf32-1
Ensembl gene	ENSG00000229891
Ensembl biotype	lncRNA
Entrez	102723775
RNAcentral	URS000075EAC2 — lncRNA, 1246 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 10 — 10 lncRNA

ENST00000412060, ENST00000424852, ENST00000432473, ENST00000653912, ENST00000669665, ENST00000814727, ENST00000814728, ENST00000814729, ENST00000814730, ENST00000814731

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000412060 — 2 exons

Exon	Start	End
ENSE00001596257	42369058	42369208
ENSE00001733357	42364402	42364725

Expression profiles

Bgee: expression breadth ubiquitous, 202 present calls, max score 91.07.

FANTOM5 (CAGE): breadth broad, TPM avg 0.7406 / max 16.3311, expressed in 355 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
194425	0.7406	355

Top tissues by expression

243 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
C1 segment of cervical spinal cord	UBERON:0006469	91.07	gold quality
spinal cord	UBERON:0002240	90.38	gold quality
upper arm skin	UBERON:0004263	88.02	silver quality
bronchial epithelial cell	CL:0002328	86.55	gold quality
epithelium of nasopharynx	UBERON:0001951	86.29	silver quality
bronchus	UBERON:0002185	86.23	gold quality
parotid gland	UBERON:0001831	86.10	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	86.00	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	84.94	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	83.26	gold quality
thyroid gland	UBERON:0002046	82.68	gold quality
kidney epithelium	UBERON:0004819	82.68	gold quality
cortical plate	UBERON:0005343	82.66	gold quality
left lobe of thyroid gland	UBERON:0001120	82.58	gold quality
mucosa of paranasal sinus	UBERON:0005030	81.79	gold quality
nasal cavity mucosa	UBERON:0001826	81.64	gold quality
substantia nigra	UBERON:0002038	81.27	gold quality
oral cavity	UBERON:0000167	81.11	silver quality
trachea	UBERON:0003126	81.03	silver quality
adenohypophysis	UBERON:0002196	81.02	gold quality
pituitary gland	UBERON:0000007	80.92	gold quality
midbrain	UBERON:0001891	80.72	gold quality
esophagus squamous epithelium	UBERON:0006920	80.72	silver quality
inferior vagus X ganglion	UBERON:0005363	80.36	silver quality
right lobe of thyroid gland	UBERON:0001119	80.24	gold quality
pancreatic ductal cell	CL:0002079	80.08	silver quality
subthalamic nucleus	UBERON:0001906	79.96	silver quality
cauda epididymis	UBERON:0004360	79.55	silver quality
medial globus pallidus	UBERON:0002477	78.80	gold quality
Ammon’s horn	UBERON:0001954	78.53	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	4.82

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 5)

• LINC01315 silencing inhibits the aggressive phenotypes of colorectal carcinoma by sponging miR-205-3p. (PMID:33162032)
• LINC01315 promotes the aggressive phenotypes of papillary thyroid cancer cells by sponging miR-497-5p. (PMID:33611825)
• LncRNA LINC01315 silencing modulates cancer stem cell properties and epithelial-to-mesenchymal transition in colorectal cancer via miR-484/DLK1 axis. (PMID:35156543)
• LINC01315 accelerates the growth and epithelial-mesenchymal transition of colorectal cancer cells via activating the Wnt/beta-catenin signal. (PMID:35322763)
• lncRNA LINC01315 promotes malignancy of triple-negative breast cancer and predicts poor outcomes by modulating microRNA-876-5p/GRK5. (PMID:35412954)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.