LINC01354

Summary

LINC01354 (long intergenic non-protein coding RNA 1354, HGNC:50581) is a long non-coding RNA gene on chromosome 1q42.2.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50581
Approved symbol	LINC01354
Name	long intergenic non-protein coding RNA 1354
Location	1q42.2
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000231768
Ensembl biotype	lncRNA
Entrez	100506795
RNAcentral	URS0000048444 — lncRNA, 2860 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 21 — 21 lncRNA

ENST00000421207, ENST00000435574, ENST00000653099, ENST00000653353, ENST00000663964, ENST00000665108, ENST00000804324, ENST00000804325, ENST00000804326, ENST00000804327, ENST00000804328, ENST00000804329, ENST00000804330, ENST00000804331, ENST00000804332, ENST00000804333, ENST00000804334, ENST00000804335, ENST00000804336, ENST00000804337, ENST00000804338

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000421207 — 2 exons

Exon	Start	End
ENSE00001616556	234529825	234530342
ENSE00003858577	234531016	234531792

Expression profiles

Bgee: expression breadth ubiquitous, 168 present calls, max score 73.17.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.3493 / max 27.6317, expressed in 139 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
18044	0.2011	77
18043	0.1481	82

Top tissues by expression

235 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
colonic epithelium	UBERON:0000397	73.17	gold quality
body of pancreas	UBERON:0001150	71.57	gold quality
caudate nucleus	UBERON:0001873	69.02	gold quality
popliteal artery	UBERON:0002250	68.76	gold quality
amygdala	UBERON:0001876	68.74	gold quality
tibial artery	UBERON:0007610	68.70	gold quality
ascending aorta	UBERON:0001496	68.59	gold quality
aorta	UBERON:0000947	68.50	gold quality
thoracic aorta	UBERON:0001515	68.49	gold quality
right coronary artery	UBERON:0001625	68.28	gold quality
descending thoracic aorta	UBERON:0002345	68.28	gold quality
hypothalamus	UBERON:0001898	68.19	gold quality
pancreas	UBERON:0001264	67.45	gold quality
left coronary artery	UBERON:0001626	66.40	gold quality
anterior cingulate cortex	UBERON:0009835	65.88	gold quality
nucleus accumbens	UBERON:0001882	65.86	gold quality
coronary artery	UBERON:0001621	65.46	gold quality
putamen	UBERON:0001874	65.41	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	65.24	gold quality
Ammon’s horn	UBERON:0001954	64.15	gold quality
ventricular zone	UBERON:0003053	64.04	gold quality
substantia nigra	UBERON:0002038	63.95	gold quality
smooth muscle tissue	UBERON:0001135	63.80	gold quality
spinal cord	UBERON:0002240	63.74	gold quality
body of uterus	UBERON:0009853	63.67	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	63.41	gold quality
temporal lobe	UBERON:0001871	62.64	gold quality
lower esophagus muscularis layer	UBERON:0035833	62.46	gold quality
lower esophagus	UBERON:0013473	62.35	gold quality
amniotic fluid	UBERON:0000173	62.01	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	7.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• LINC01354 was upregulated in CRC tissues and high level of LINC01354 was associated with poor prognosis of CRC patients. Gain- and loss-of-function assays illustrated that LINC01354 acted as an oncogene in CRC to facilitate tumor cell proliferation, inhibited apoptosis, and promoted cell migration and invasion in an hnRNP-D/Wnt/beta-catenin-dependent manner (PMID:30987669)
• LINC01354 enhances the proliferation and invasion of lung cancer cells by regulating miR-340-5p/ATF1 signaling pathway (PMID:31538498)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.