LINC01376

Summary

LINC01376 (long intergenic non-protein coding RNA 1376, HGNC:50637) is a long non-coding RNA gene on chromosome 2p24.2-p24.1.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50637
Approved symbol	LINC01376
Name	long intergenic non-protein coding RNA 1376
Location	2p24.2-p24.1
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000236204
Ensembl biotype	lncRNA
Entrez	400945
RNAcentral	URS0000770BFF — lncRNA, 1949 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 60 — 60 lncRNA

ENST00000418165, ENST00000424895, ENST00000432142, ENST00000449124, ENST00000650025, ENST00000702731, ENST00000776433, ENST00000776434, ENST00000776435, ENST00000776436, ENST00000776437, ENST00000776438, ENST00000776439, ENST00000776440, ENST00000776441, ENST00000776442, ENST00000776443, ENST00000776444, ENST00000776445, ENST00000776446, ENST00000776447, ENST00000776448, ENST00000776449, ENST00000776450, ENST00000776451, ENST00000776452, ENST00000776453, ENST00000776454, ENST00000776455, ENST00000776456, ENST00000776457, ENST00000776458, ENST00000776459, ENST00000776460, ENST00000776461, ENST00000776462, ENST00000776463, ENST00000776464, ENST00000776465, ENST00000776466, ENST00000776467, ENST00000776468, ENST00000776469, ENST00000776470, ENST00000776471, ENST00000776472, ENST00000776473, ENST00000776474, ENST00000776475, ENST00000776476, ENST00000776477, ENST00000776478, ENST00000776479, ENST00000776480, ENST00000776481, ENST00000776482, ENST00000776483, ENST00000776484, ENST00000776485, ENST00000776486

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000418165 — 5 exons

Exon	Start	End
ENSE00001626995	19125252	19125387
ENSE00001656510	19305823	19306037
ENSE00001709360	19026660	19026705
ENSE00001742729	19084927	19085025
ENSE00001769468	19031324	19031380

Expression profiles

Bgee: expression breadth ubiquitous, 131 present calls, max score 81.32.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 4.0068 / max 43.0608, expressed in 1532 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
27055	4.0068	1532

Top tissues by expression

131 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	81.32	gold quality
colonic epithelium	UBERON:0000397	80.56	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	79.44	gold quality
bone marrow cell	CL:0002092	76.75	gold quality
right uterine tube	UBERON:0001302	69.60	gold quality
sural nerve	UBERON:0015488	69.43	gold quality
bone marrow	UBERON:0002371	69.25	gold quality
calcaneal tendon	UBERON:0003701	69.23	gold quality
placenta	UBERON:0001987	65.39	gold quality
tibial artery	UBERON:0007610	65.38	gold quality
popliteal artery	UBERON:0002250	65.37	gold quality
skeletal muscle tissue	UBERON:0001134	65.11	gold quality
islet of Langerhans	UBERON:0000006	64.91	gold quality
pancreas	UBERON:0001264	64.53	gold quality
mucosa of stomach	UBERON:0001199	64.35	gold quality
urinary bladder	UBERON:0001255	64.22	gold quality
body of pancreas	UBERON:0001150	64.21	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	63.95	gold quality
fallopian tube	UBERON:0003889	62.97	gold quality
hindlimb stylopod muscle	UBERON:0004252	62.44	gold quality
endometrium	UBERON:0001295	62.20	gold quality
ventricular zone	UBERON:0003053	61.82	gold quality
smooth muscle tissue	UBERON:0001135	61.71	gold quality
right adrenal gland cortex	UBERON:0035827	61.69	gold quality
thoracic mammary gland	UBERON:0005200	61.49	gold quality
tibial nerve	UBERON:0001323	61.32	gold quality
lower esophagus muscularis layer	UBERON:0035833	61.26	gold quality
lower esophagus	UBERON:0013473	61.20	gold quality
descending thoracic aorta	UBERON:0002345	61.08	gold quality
cortical plate	UBERON:0005343	61.06	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	4.44

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• LINC01376 promotes nasopharyngeal carcinoma tumorigenesis by competitively binding to the SP1/miR-4757/IGF1 axis. (PMID:36973940)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.