LINC01410

Summary

LINC01410 (long intergenic non-protein coding RNA 1410, HGNC:50702) is a long non-coding RNA gene on chromosome 9q13.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50702
Approved symbol	LINC01410
Name	long intergenic non-protein coding RNA 1410
Location	9q13
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000238113
Ensembl biotype	lncRNA
Entrez	103352539
RNAcentral	URS000056E99A — lncRNA, 2877 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 39 — 39 lncRNA

ENST00000424345, ENST00000427509, ENST00000452184, ENST00000650319, ENST00000659835, ENST00000660304, ENST00000663670, ENST00000664868, ENST00000667536, ENST00000848964, ENST00000848965, ENST00000848966, ENST00000848967, ENST00000848968, ENST00000848969, ENST00000848970, ENST00000848971, ENST00000848972, ENST00000848973, ENST00000848974, ENST00000848975, ENST00000848976, ENST00000848977, ENST00000848978, ENST00000848979, ENST00000848980, ENST00000848981, ENST00000848982, ENST00000848983, ENST00000848984, ENST00000848985, ENST00000848986, ENST00000848987, ENST00000849325, ENST00000849326, ENST00000849327, ENST00000849328, ENST00000849329, ENST00000849330

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000424345 — 5 exons

Exon	Start	End
ENSE00001690978	62803984	62804140
ENSE00001737953	62812793	62813486
ENSE00001765389	62811939	62812075
ENSE00004279708	62809768	62811589
ENSE00004279714	62801443	62801531

Expression profiles

Bgee: expression breadth ubiquitous, 163 present calls, max score 93.89.

Top tissues by expression

245 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
monocyte	CL:0000576	93.89	gold quality
leukocyte	CL:0000738	93.43	gold quality
granulocyte	CL:0000094	88.67	gold quality
sural nerve	UBERON:0015488	84.97	gold quality
spleen	UBERON:0002106	84.64	gold quality
adenohypophysis	UBERON:0002196	83.33	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	83.32	gold quality
bone marrow cell	CL:0002092	82.98	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	82.84	gold quality
blood	UBERON:0000178	82.04	gold quality
vermiform appendix	UBERON:0001154	81.13	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	80.77	gold quality
pituitary gland	UBERON:0000007	80.47	gold quality
tibial nerve	UBERON:0001323	79.28	gold quality
spinal cord	UBERON:0002240	77.13	gold quality
cortical plate	UBERON:0005343	76.69	gold quality
ventricular zone	UBERON:0003053	76.17	gold quality
right hemisphere of cerebellum	UBERON:0014890	75.95	gold quality
right lobe of thyroid gland	UBERON:0001119	75.29	gold quality
cerebellar hemisphere	UBERON:0002245	74.84	gold quality
cerebellar cortex	UBERON:0002129	74.65	gold quality
small intestine Peyer’s patch	UBERON:0003454	74.33	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	74.26	gold quality
bone marrow	UBERON:0002371	74.07	gold quality
left lobe of thyroid gland	UBERON:0001120	73.93	gold quality
lymph node	UBERON:0000029	73.85	gold quality
right lung	UBERON:0002167	73.82	gold quality
upper lobe of left lung	UBERON:0008952	73.45	gold quality
omental fat pad	UBERON:0010414	73.19	gold quality
apex of heart	UBERON:0002098	73.12	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	8.08

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 12)

• Down-regulation of LINC01410 expression inhibits the proliferation and migration of pancreatic cancer BxPC-3 cells (PMID:31137129)
• The expression of long intergenic non-protein coding RNA 1410 (LINC01410) is elevated in papillary thyroid carcinoma (TC) cells. LINC01410 knockdown suppresses proliferation and facilitated apoptosis in TC. LINC01410 positively regulates forkhead box M1 (FOXM1) expression through targeting miR-3619-5p, and that FOXM1 in turn transcriptionally activates LINC01410. (PMID:31644316)
• LINC01410 promotes cell proliferation and migration of cholangiocarcinoma through modulating miR-124-3p/SMAD5 axis. (PMID:31951299)
• LINC01410/miR-23c/CHD7 functions as a ceRNA network to affect the prognosis of patients with endometrial cancer and strengthen the malignant properties of endometrial cancer cells. (PMID:32314193)
• Long noncoding RNA LINC01410 promotes the tumorigenesis of neuroblastoma cells by sponging microRNA-506-3p and modulating WEE1. (PMID:32886453)
• LINC01410 accelerated the invasion and proliferation of osteosarcoma by sponging miR-3128. (PMID:33401246)
• The LINC01410/miR-122-5p/NDRG3 axis is involved in the proliferation and migration of osteosarcoma cells. (PMID:33583123)
• LncRNA LINC01410 Induced by MYC Accelerates Glioma Progression via Sponging miR-506-3p and Modulating NOTCH2 Expression to Motivate Notch Signaling Pathway. (PMID:33712887)
• High Expression of Long Noncoding RNA 01410 Serves as a Potential Diagnostic and Prognostic Marker in Patients with Colorectal Cancer. (PMID:33978387)
• Silencing lncRNA LINC01410 suppresses cell viability yet promotes apoptosis and sensitivity to temozolomide in glioblastoma cells by inactivating PTEN/AKT pathway via targeting miR-370-3p. (PMID:34435542)
• Long noncoding RNA LINC01410 promotes tumorigenesis of osteosarcoma cells via miR-497-5p/HMGA2 axis. (PMID:34605103)
• Misexpression of LINC01410, FOSL1, and MAFB in peripheral blood mononuclear cells associated with diabetic nephropathy. (PMID:36764337)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.