LINC01422

Summary

LINC01422 (long intergenic non-protein coding RNA 1422, HGNC:50728) is a long non-coding RNA gene on chromosome 22q12.1.

At a glance

• GWAS associations: 1

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50728
Approved symbol	LINC01422
Name	long intergenic non-protein coding RNA 1422
Location	22q12.1
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000223704
Entrez	101929539
RNAcentral	URS000075B4F7 — lncRNA, 565 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 0

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

None — 0 exons

Expression profiles

Bgee: expression breadth ubiquitous, 134 present calls, max score 83.82.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.0212 / max 13.5325, expressed in 8 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
191536	0.0212	8

Top tissues by expression

134 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	83.82	gold quality
bone marrow cell	CL:0002092	75.70	gold quality
granulocyte	CL:0000094	73.82	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	72.97	gold quality
sural nerve	UBERON:0015488	72.75	gold quality
right uterine tube	UBERON:0001302	68.49	gold quality
colonic epithelium	UBERON:0000397	68.38	silver quality
tonsil	UBERON:0002372	68.01	gold quality
blood	UBERON:0000178	67.57	gold quality
spleen	UBERON:0002106	66.78	gold quality
bone marrow	UBERON:0002371	66.52	gold quality
hindlimb stylopod muscle	UBERON:0004252	65.01	gold quality
mucosa of stomach	UBERON:0001199	64.89	gold quality
skin of leg	UBERON:0001511	64.89	gold quality
zone of skin	UBERON:0000014	64.84	gold quality
skin of abdomen	UBERON:0001416	64.54	gold quality
right adrenal gland cortex	UBERON:0035827	64.46	gold quality
skeletal muscle tissue	UBERON:0001134	64.04	gold quality
lymph node	UBERON:0000029	63.74	gold quality
apex of heart	UBERON:0002098	63.64	gold quality
ventricular zone	UBERON:0003053	63.42	gold quality
small intestine Peyer’s patch	UBERON:0003454	63.03	gold quality
right adrenal gland	UBERON:0001233	62.89	gold quality
right coronary artery	UBERON:0001625	62.75	gold quality
lower esophagus muscularis layer	UBERON:0035833	62.49	gold quality
small intestine	UBERON:0002108	62.44	gold quality
lower esophagus	UBERON:0013473	62.44	gold quality
omental fat pad	UBERON:0010414	62.42	gold quality
muscle tissue	UBERON:0002385	62.37	gold quality
left adrenal gland	UBERON:0001234	62.25	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	5.19

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Protein identifiers

Canonical reviewed UniProt: None (reviewed: )

All UniProt accessions (0):

RefSeq proteins (0): (*=MANE)

Domains & families (InterPro)

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 0 (showing top):

GO Biological Process (0):

GO Molecular Function (0):

GO Cellular Component (0):

Protein interactions and networks

STRING

0 interactions, top by confidence (×1000):

IntAct

0 interactions, top by confidence:

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

0 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

0 predictions. Top by Δscore:

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000065725 (22:26919232 T>C), RS1000143687 (22:26917832 C>T), RS1000199648 (22:26914129 T>A), RS1000473849 (22:26908981 C>T), RS1000506005 (22:26914839 C>A,G,T), RS1000600771 (22:26914643 C>G,T), RS1000783535 (22:26910169 C>T), RS1000938140 (22:26904847 G>T), RS1001092278 (22:26919097 C>T), RS1001186936 (22:26908931 A>C,G), RS1001215762 (22:26910375 T>C), RS1001268542 (22:26906203 C>A,T), RS1001324707 (22:26903981 C>T), RS1001360001 (22:26908987 A>C,G), RS1001867395 (22:26908708 G>A)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

1 associations (top):

Study	Trait	p-value
GCST003631_7	Gastroesophageal reflux disease	7.000000e-06

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 0 entries

CTD chemical–gene interactions

3 total (human), top 3 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
aristolochic acid I	decreases expression	1
sodium arsenite	increases expression	1
Smoke	increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.