LINC01426

Summary

LINC01426 (long intergenic non-protein coding RNA 1426, HGNC:50734) is a long non-coding RNA gene on chromosome 21q22.12.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50734
Approved symbol	LINC01426
Name	long intergenic non-protein coding RNA 1426
Location	21q22.12
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000234380
Ensembl biotype	lncRNA
Entrez	100506385
RNAcentral	URS000075E64A — lncRNA, 2564 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 6 — 6 lncRNA

ENST00000419921, ENST00000420877, ENST00000652751, ENST00000729717, ENST00000729718, ENST00000729719

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000419921 — 2 exons

Exon	Start	End
ENSE00001600687	34745837	34746016
ENSE00001787250	34747781	34748367

Expression profiles

Bgee: expression breadth ubiquitous, 134 present calls, max score 77.82.

FANTOM5 (CAGE): breadth broad, TPM avg 0.9148 / max 19.4661, expressed in 486 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
188939	0.8338	461
188940	0.0810	20

Top tissues by expression

225 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	77.82	silver quality
bone marrow cell	CL:0002092	69.50	silver quality
left coronary artery	UBERON:0001626	63.42	gold quality
right coronary artery	UBERON:0001625	62.08	gold quality
coronary artery	UBERON:0001621	62.00	gold quality
gall bladder	UBERON:0002110	61.77	gold quality
buccal mucosa cell	CL:0002336	61.26	gold quality
islet of Langerhans	UBERON:0000006	59.89	gold quality
stromal cell of endometrium	CL:0002255	59.58	gold quality
ganglionic eminence	UBERON:0004023	59.08	silver quality
hindlimb stylopod muscle	UBERON:0004252	56.68	gold quality
pancreas	UBERON:0001264	56.22	gold quality
metanephros cortex	UBERON:0010533	55.88	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	55.18	gold quality
vermiform appendix	UBERON:0001154	55.13	gold quality
right atrium auricular region	UBERON:0006631	54.88	gold quality
body of pancreas	UBERON:0001150	54.71	gold quality
cortex of kidney	UBERON:0001225	54.65	gold quality
cardiac atrium	UBERON:0002081	54.48	gold quality
right lobe of thyroid gland	UBERON:0001119	54.20	gold quality
omental fat pad	UBERON:0010414	53.88	gold quality
peritoneum	UBERON:0002358	53.84	gold quality
subcutaneous adipose tissue	UBERON:0002190	53.54	gold quality
body of stomach	UBERON:0001161	53.36	gold quality
heart	UBERON:0000948	53.26	gold quality
adipose tissue of abdominal region	UBERON:0007808	53.14	gold quality
apex of heart	UBERON:0002098	53.09	gold quality
monocyte	CL:0000576	53.01	silver quality
tibial artery	UBERON:0007610	52.87	gold quality
popliteal artery	UBERON:0002250	52.86	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	3.98

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 5)

• These results indicated that lincRNA-uc002yug.2 might involve in AS of RUNX1/AML1 and serve as a predictor for esophageal cancer and prognosis. (PMID:25486427)
• LINC01426 functions as a tumor promoter in glioma by modulating PI3K/Akt signaling pathway to promote disease progression. (PMID:30338804)
• Upregulation of LINC01426 promotes the progression and stemness in lung adenocarcinoma by enhancing the level of SHH protein to activate the hedgehog pathway. (PMID:33568633)
• Long noncoding RNA LINC01426 promotes the progression of lung adenocarcinoma via regulating miRNA-125a-5p/ casein kinase 2 alpha 1 axis. (PMID:35266446)
• Long Non-coding RNA LINC01426 Contributes to the Malignant Behaviors of NSCLC Via Acting As a Sponge for miR-143-3p. (PMID:35639219)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.