LINC01433

Summary

LINC01433 (long intergenic non-protein coding RNA 1433, HGNC:50746) is a long non-coding RNA gene on chromosome 20p13.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50746
Approved symbol	LINC01433
Name	long intergenic non-protein coding RNA 1433
Location	20p13
Locus type	RNA, long non-coding
Status	Approved
Aliases	LOC728228
Ensembl gene	ENSG00000230176
Ensembl biotype	lncRNA
Entrez	728228
RNAcentral	URS000075ECD9 — lncRNA, 692 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 2 — 2 lncRNA

ENST00000419003, ENST00000658198

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000419003 — 3 exons

Exon	Start	End
ENSE00001735201	4193043	4193246
ENSE00001752542	4195526	4195933
ENSE00003861720	4195175	4195378

Expression profiles

Bgee: expression breadth broad, 100 present calls, max score 97.40.

Top tissues by expression

100 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	97.40	silver quality
ganglionic eminence	UBERON:0004023	65.59	gold quality
ventricular zone	UBERON:0003053	63.16	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	61.09	gold quality
bone marrow	UBERON:0002371	59.54	gold quality
stromal cell of endometrium	CL:0002255	56.14	gold quality
monocyte	CL:0000576	54.79	gold quality
descending thoracic aorta	UBERON:0002345	54.51	gold quality
gall bladder	UBERON:0002110	53.40	gold quality
cortex of kidney	UBERON:0001225	53.00	gold quality
liver	UBERON:0002107	52.15	silver quality
blood	UBERON:0000178	51.79	gold quality
placenta	UBERON:0001987	51.18	gold quality
right lobe of liver	UBERON:0001114	50.87	silver quality
prefrontal cortex	UBERON:0000451	50.75	gold quality
duodenum	UBERON:0002114	50.10	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	49.79	gold quality
islet of Langerhans	UBERON:0000006	49.51	gold quality
omental fat pad	UBERON:0010414	49.43	gold quality
urinary bladder	UBERON:0001255	48.40	gold quality
adipose tissue	UBERON:0001013	47.66	gold quality
stomach	UBERON:0000945	46.97	gold quality
body of stomach	UBERON:0001161	46.89	gold quality
lymph node	UBERON:0000029	46.76	silver quality
myometrium	UBERON:0001296	46.37	gold quality
muscle of leg	UBERON:0001383	45.69	silver quality
body of uterus	UBERON:0009853	45.49	gold quality
fundus of stomach	UBERON:0001160	45.17	gold quality
gastrocnemius	UBERON:0001388	45.17	silver quality
endometrium	UBERON:0001295	45.08	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.42

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 7)

• Linc01433 overexpression in lung cancer cells increased proliferation, migration, and invasion abilities, as well as epithelial-to-mesenchymal transition. Linc01433 is a cancer-related lncRNA that may have an oncogene-like effect in non-small cell lung cancer. (PMID:29532622)
• LINC01433 participated in hepatocellular carcinoma progression through modulating the miR-1301/STAT3 axis (PMID:30317567)
• High LINC01433 expression is associated with Cell Proliferation, Migration, and the Epithelial-Mesenchymal Transition in Breast Cancer. (PMID:30939038)
• Based on the similar expression levels of LINC01433 between non-small cell lung cancer and non-tumoral tissues and lack of association between expression levels and clinical data, LINC01433 is not a possible contributor to lung cancer in Iranian patients. (PMID:31842564)
• Long non-coding RNA linc01433 promotes tumorigenesis and progression in esophageal squamous cell carcinoma by sponging miR-1301. (PMID:32432741)
• LINC01433 targets miR-506-3p to promote the biological progress of nasopharyngeal carcinoma cells. (PMID:33479848)
• Uncovering the relationship between YAP/ WWTR1 (TAZ) genes expression and LncRNAs of SNHG15, HCP5 and LINC01433 in breast cancer tissues. (PMID:38599044)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.