LINC01436

Summary

LINC01436 (long intergenic non-protein coding RNA 1436, HGNC:50754) is a long non-coding RNA gene on chromosome 21q22.12.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50754
Approved symbol	LINC01436
Name	long intergenic non-protein coding RNA 1436
Location	21q22.12
Locus type	RNA, long non-coding
Status	Approved
Aliases	AP000688.8
Ensembl gene	ENSG00000231106
Ensembl biotype	lncRNA
Entrez	100996609
RNAcentral	URS000075C2DF — lncRNA, 1523 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 lncRNA

ENST00000457157

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000457157 — 2 exons

Exon	Start	End
ENSE00004131957	36005131	36005865
ENSE00004131958	36007319	36008300

Expression profiles

Bgee: expression breadth ubiquitous, 117 present calls, max score 87.12.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.1103 / max 9.5268, expressed in 47 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
188974	0.0725	31
188975	0.0378	19

Top tissues by expression

117 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	87.12	gold quality
calcaneal tendon	UBERON:0003701	86.37	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	80.40	gold quality
mucosa of stomach	UBERON:0001199	73.80	gold quality
gall bladder	UBERON:0002110	71.97	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	71.70	gold quality
colonic epithelium	UBERON:0000397	68.41	silver quality
subcutaneous adipose tissue	UBERON:0002190	65.56	gold quality
cortical plate	UBERON:0005343	65.32	gold quality
mucosa of transverse colon	UBERON:0004991	65.23	gold quality
duodenum	UBERON:0002114	65.20	gold quality
vermiform appendix	UBERON:0001154	63.82	gold quality
skin of leg	UBERON:0001511	63.69	gold quality
muscle layer of sigmoid colon	UBERON:0035805	63.03	gold quality
rectum	UBERON:0001052	62.59	gold quality
adipose tissue	UBERON:0001013	62.36	gold quality
minor salivary gland	UBERON:0001830	61.88	gold quality
zone of skin	UBERON:0000014	61.84	gold quality
saliva-secreting gland	UBERON:0001044	61.50	gold quality
colon	UBERON:0001155	61.06	gold quality
thoracic mammary gland	UBERON:0005200	61.00	gold quality
intestine	UBERON:0000160	60.79	gold quality
hindlimb stylopod muscle	UBERON:0004252	60.05	gold quality
small intestine	UBERON:0002108	60.03	gold quality
endocervix	UBERON:0000458	59.96	gold quality
lower esophagus mucosa	UBERON:0035834	59.55	gold quality
skin of abdomen	UBERON:0001416	59.20	gold quality
right lung	UBERON:0002167	59.14	gold quality
skeletal muscle tissue	UBERON:0001134	58.99	gold quality
vagina	UBERON:0000996	58.97	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.82

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• LINC01436, regulating miR-585 and FBXO11, is an oncogenic lncRNA in the progression of gastric cancer. (PMID:31829474)
• LINC01436 Inhibited miR-585-3p Expression and Upregulated MAPK1 Expression to Promote Gastric Cancer Progression. (PMID:32820394)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.