LINC01446

Summary

LINC01446 (long intergenic non-protein coding RNA 1446, HGNC:50773) is a long non-coding RNA gene on chromosome 7p12.1.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50773
Approved symbol	LINC01446
Name	long intergenic non-protein coding RNA 1446
Location	7p12.1
Locus type	RNA, long non-coding
Status	Approved
Aliases	FLJ45974
Ensembl gene	ENSG00000205628
Ensembl biotype	lncRNA
Entrez	401337
RNAcentral	URS00003AA7A2 — lncRNA, 3484 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 42 — 42 lncRNA

ENST00000380970, ENST00000650830, ENST00000651244, ENST00000651506, ENST00000651858, ENST00000651951, ENST00000652029, ENST00000652104, ENST00000652440, ENST00000654050, ENST00000656718, ENST00000656885, ENST00000658338, ENST00000659250, ENST00000659481, ENST00000659794, ENST00000660413, ENST00000660945, ENST00000660958, ENST00000661502, ENST00000662259, ENST00000662931, ENST00000663138, ENST00000663312, ENST00000663872, ENST00000665927, ENST00000666213, ENST00000668489, ENST00000669638, ENST00000670507, ENST00000670902, ENST00000670945, ENST00000765736, ENST00000765737, ENST00000765738, ENST00000765739, ENST00000765740, ENST00000765741, ENST00000765742, ENST00000765743, ENST00000765744, ENST00000765745

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000380970 — 6 exons

Exon	Start	End
ENSE00001487005	53779946	53780038
ENSE00001487007	53811508	53811931
ENSE00001534884	53655509	53657448
ENSE00001534885	53691927	53692089
ENSE00001534886	53765127	53765245
ENSE00001534889	53765483	53766227

Expression profiles

Bgee: expression breadth ubiquitous, 120 present calls, max score 82.42.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.7879 / max 54.1666, expressed in 130 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
84128	0.7879	130

Top tissues by expression

120 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	82.42	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	81.58	gold quality
placenta	UBERON:0001987	74.95	gold quality
mucosa of transverse colon	UBERON:0004991	63.00	gold quality
cortical plate	UBERON:0005343	61.29	gold quality
ganglionic eminence	UBERON:0004023	60.90	gold quality
sural nerve	UBERON:0015488	60.81	gold quality
ventricular zone	UBERON:0003053	60.65	gold quality
skeletal muscle tissue	UBERON:0001134	57.37	gold quality
cortex of kidney	UBERON:0001225	56.09	gold quality
testis	UBERON:0000473	56.04	gold quality
right testis	UBERON:0004534	55.36	gold quality
liver	UBERON:0002107	54.82	gold quality
islet of Langerhans	UBERON:0000006	54.59	gold quality
right adrenal gland cortex	UBERON:0035827	54.13	gold quality
monocyte	CL:0000576	54.08	gold quality
tonsil	UBERON:0002372	53.91	gold quality
left testis	UBERON:0004533	53.50	gold quality
right lobe of liver	UBERON:0001114	53.48	gold quality
bone marrow	UBERON:0002371	52.92	silver quality
endometrium	UBERON:0001295	51.81	gold quality
blood	UBERON:0000178	51.79	gold quality
pancreas	UBERON:0001264	51.45	gold quality
adrenal tissue	UBERON:0018303	51.40	gold quality
lymph node	UBERON:0000029	51.27	gold quality
prefrontal cortex	UBERON:0000451	50.91	gold quality
duodenum	UBERON:0002114	50.09	gold quality
calcaneal tendon	UBERON:0003701	50.08	silver quality
mucosa of stomach	UBERON:0001199	50.07	gold quality
corpus callosum	UBERON:0002336	49.98	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	5.36

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.