LINC01503

Summary

LINC01503 (long intergenic non-protein coding RNA 1503, HGNC:51184) is a long non-coding RNA gene on chromosome 9q34.11.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:51184
Approved symbol	LINC01503
Name	long intergenic non-protein coding RNA 1503
Location	9q34.11
Locus type	RNA, long non-coding
Status	Approved
Aliases	lnc-PPP2R4-5, RP11-65J3.1
Ensembl gene	ENSG00000233901
Ensembl biotype	lncRNA
Entrez	100506119
RNAcentral	URS000075D06E — lncRNA, 752 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 27 — 27 lncRNA

ENST00000316786, ENST00000423122, ENST00000427109, ENST00000436710, ENST00000444125, ENST00000599815, ENST00000654148, ENST00000654190, ENST00000654735, ENST00000657393, ENST00000657651, ENST00000657886, ENST00000659864, ENST00000660036, ENST00000660635, ENST00000661745, ENST00000665063, ENST00000666671, ENST00000667257, ENST00000690929, ENST00000701282, ENST00000701775, ENST00000716744, ENST00000716745, ENST00000716746, ENST00000716747, ENST00000716748

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000316786 — 2 exons

Exon	Start	End
ENSE00001236621	129321016	129321046
ENSE00001236630	129321792	129324905

Expression profiles

Bgee: expression breadth ubiquitous, 176 present calls, max score 90.16.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 7.8362 / max 171.0452, expressed in 1257 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
98906	4.1022	987
98902	2.7442	227
98904	0.7196	396
98903	0.2702	155

Top tissues by expression

248 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
metanephros cortex	UBERON:0010533	90.16	gold quality
monocyte	CL:0000576	84.99	gold quality
leukocyte	CL:0000738	84.60	gold quality
adult mammalian kidney	UBERON:0000082	84.49	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	84.45	gold quality
ectocervix	UBERON:0012249	83.50	gold quality
endocervix	UBERON:0000458	82.86	gold quality
cortical plate	UBERON:0005343	82.48	gold quality
vagina	UBERON:0000996	82.23	gold quality
lower esophagus mucosa	UBERON:0035834	81.40	gold quality
ganglionic eminence	UBERON:0004023	81.36	gold quality
esophagus mucosa	UBERON:0002469	81.16	gold quality
skin of abdomen	UBERON:0001416	81.00	gold quality
spleen	UBERON:0002106	80.77	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	80.35	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	80.14	gold quality
granulocyte	CL:0000094	79.94	gold quality
skin of leg	UBERON:0001511	79.09	gold quality
anterior cingulate cortex	UBERON:0009835	78.88	gold quality
descending thoracic aorta	UBERON:0002345	78.47	gold quality
zone of skin	UBERON:0000014	78.20	gold quality
uterine cervix	UBERON:0000002	78.00	gold quality
kidney	UBERON:0002113	77.94	gold quality
kidney epithelium	UBERON:0004819	77.74	gold quality
Brodmann (1909) area 9	UBERON:0013540	77.71	gold quality
blood	UBERON:0000178	77.44	gold quality
stromal cell of endometrium	CL:0002255	77.34	gold quality
caudate nucleus	UBERON:0001873	77.30	gold quality
cortex of kidney	UBERON:0001225	77.11	gold quality
urinary bladder	UBERON:0001255	77.08	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	7.75

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 11)

• LINC01503 is increased in squamous cell carcinoma (SCC) cells compared with non-tumor cells. TP63 bound to the super enhancer at the LINC01503 locus activates its transcription which promotes SCC cell proliferation, migration, invasion, and growth of xenograft tumors. (PMID:29454790)
• findings suggested that LINC01503 conferred oncogenic function in glioma and may be a new prognostic biomarker and novel therapeutic strategy for this malignancy (PMID:30840283)
• LINC01503 promotes cell proliferation, invasion and EMT process in cholangio-carcinoma. (PMID:31378883)
• Long Non-coding RNA LINC01503 Promotes Gastric Cancer Cell Proliferation and Invasion by Regulating Wnt Signaling. (PMID:32207034)
• LncRNA LINC01503 aggravates the progression of cervical cancer through sponging miR-342-3p to mediate FXYD3 expression. (PMID:32432654)
• AR-induced long non-coding RNA LINC01503 facilitates proliferation and metastasis via the SFPQ-FOSL1 axis in nasopharyngeal carcinoma. (PMID:32661324)
• LINC01503/miR-342-3p facilitates malignancy in non-small-cell lung cancer cells via regulating LASP1. (PMID:32938459)
• EGR1-mediated linc01503 promotes cell cycle progression and tumorigenesis in gastric cancer. (PMID:33145887)
• C-MYC-induced upregulation of LINC01503 promotes progression of non-small cell lung cancer. (PMID:33215429)
• The transcript ENST00000444125 of lncRNA LINC01503 promotes cancer stem cell properties of glioblastoma cells via reducing FBXW1 mediated GLI2 degradation. (PMID:34990616)
• Roles, underlying mechanisms and clinical significances of LINC01503 in human cancers. (PMID:38241778)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.