LINC01518

Summary

LINC01518 (long intergenic non-protein coding RNA 1518, HGNC:51216) is a long non-coding RNA gene on chromosome 10q11.21.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:51216
Approved symbol	LINC01518
Name	long intergenic non-protein coding RNA 1518
Location	10q11.21
Locus type	RNA, long non-coding
Status	Approved
Aliases	JINR1
Ensembl gene	ENSG00000233515
Ensembl biotype	lncRNA
Entrez	101929397
RNAcentral	URS000075CDAB — lncRNA, 1856 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 10 — 10 lncRNA

ENST00000411439, ENST00000662977, ENST00000668437, ENST00000736721, ENST00000736722, ENST00000736723, ENST00000736724, ENST00000736725, ENST00000736726, ENST00000736727

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000411439 — 5 exons

Exon	Start	End
ENSE00001621153	42674224	42674357
ENSE00001700264	42685951	42686016
ENSE00001706118	42683358	42683460
ENSE00003877307	42690733	42690842
ENSE00003878142	42691535	42691721

Expression profiles

Bgee: expression breadth ubiquitous, 111 present calls, max score 85.23.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.4657 / max 77.0018, expressed in 71 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
109153	0.4368	66
205826	0.0288	16

Top tissues by expression

111 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	85.23	gold quality
testis	UBERON:0000473	79.06	gold quality
left testis	UBERON:0004533	78.73	gold quality
right testis	UBERON:0004534	78.70	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	76.69	gold quality
sural nerve	UBERON:0015488	67.23	silver quality
ventricular zone	UBERON:0003053	61.72	gold quality
hindlimb stylopod muscle	UBERON:0004252	61.00	gold quality
stromal cell of endometrium	CL:0002255	56.58	gold quality
bone marrow	UBERON:0002371	54.59	gold quality
cortical plate	UBERON:0005343	53.53	silver quality
monocyte	CL:0000576	51.90	silver quality
blood	UBERON:0000178	51.89	gold quality
placenta	UBERON:0001987	51.30	gold quality
urinary bladder	UBERON:0001255	50.86	gold quality
endometrium	UBERON:0001295	49.69	gold quality
lymph node	UBERON:0000029	48.82	gold quality
vermiform appendix	UBERON:0001154	48.82	gold quality
prefrontal cortex	UBERON:0000451	47.95	silver quality
muscle of leg	UBERON:0001383	47.88	gold quality
pituitary gland	UBERON:0000007	47.79	gold quality
right uterine tube	UBERON:0001302	47.57	gold quality
primary visual cortex	UBERON:0002436	47.48	silver quality
adenohypophysis	UBERON:0002196	47.19	gold quality
liver	UBERON:0002107	47.08	silver quality
multicellular organism	UBERON:0000468	46.70	gold quality
superior frontal gyrus	UBERON:0002661	46.57	silver quality
islet of Langerhans	UBERON:0000006	46.49	silver quality
gastrocnemius	UBERON:0001388	46.27	gold quality
pancreas	UBERON:0001264	46.13	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.79

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• LINC01518 knockdown inhibited tumorigenicity in ESCC cells by suppression of PIK3CA/Akt pathway through upregulating miR-1-3p (PMID:31810385)
• Long Noncoding RNA LINC01518 Modulates Proliferation and Migration in TGF-beta1-Treated Human Tenon Capsule Fibroblast Cells Through the Regulation of hsa-miR-216b-5p. (PMID:33993456)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.