LINC01535

Summary

LINC01535 (long intergenic non-protein coding RNA 1535, HGNC:51282) is a long non-coding RNA gene on chromosome 19q13.12.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:51282
Approved symbol	LINC01535
Name	long intergenic non-protein coding RNA 1535
Location	19q13.12
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000226686
Ensembl biotype	lncRNA
Entrez	101927667
RNAcentral	URS0000D78147 — lncRNA, 888 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 30 — 30 lncRNA

ENST00000438770, ENST00000587477, ENST00000588904, ENST00000591116, ENST00000592100, ENST00000592712, ENST00000659822, ENST00000659928, ENST00000664190, ENST00000666743, ENST00000685471, ENST00000688387, ENST00000692449, ENST00000702853, ENST00000702889, ENST00000702899, ENST00000818221, ENST00000818222, ENST00000818223, ENST00000818224, ENST00000818225, ENST00000818226, ENST00000818227, ENST00000818228, ENST00000818229, ENST00000818230, ENST00000818231, ENST00000818232, ENST00000818233, ENST00000818234

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000438770 — 4 exons

Exon	Start	End
ENSE00001795393	37255899	37255982
ENSE00002784700	37251912	37252182
ENSE00002803982	37262542	37262655
ENSE00002836295	37263679	37263762

Expression profiles

Bgee: expression breadth ubiquitous, 134 present calls, max score 82.40.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 3.5829 / max 88.6005, expressed in 946 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
175543	3.5829	946

Top tissues by expression

134 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	82.40	gold quality
apex of heart	UBERON:0002098	82.37	gold quality
bone marrow cell	CL:0002092	82.32	gold quality
superior frontal gyrus	UBERON:0002661	81.46	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	80.98	gold quality
putamen	UBERON:0001874	78.88	gold quality
primary visual cortex	UBERON:0002436	78.27	gold quality
caudate nucleus	UBERON:0001873	78.05	gold quality
nucleus accumbens	UBERON:0001882	78.00	gold quality
pituitary gland	UBERON:0000007	77.93	gold quality
amygdala	UBERON:0001876	77.51	gold quality
temporal lobe	UBERON:0001871	77.43	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	77.36	gold quality
hypothalamus	UBERON:0001898	77.33	gold quality
anterior cingulate cortex	UBERON:0009835	77.14	gold quality
adenohypophysis	UBERON:0002196	76.99	gold quality
right frontal lobe	UBERON:0002810	76.89	gold quality
brain	UBERON:0000955	76.79	gold quality
Ammon’s horn	UBERON:0001954	76.73	gold quality
right hemisphere of cerebellum	UBERON:0014890	76.62	gold quality
substantia nigra	UBERON:0002038	76.36	gold quality
Brodmann (1909) area 9	UBERON:0013540	76.31	gold quality
cerebellar cortex	UBERON:0002129	76.19	gold quality
cerebellum	UBERON:0002037	76.18	gold quality
heart left ventricle	UBERON:0002084	76.17	gold quality
cerebellar hemisphere	UBERON:0002245	76.14	gold quality
cerebral cortex	UBERON:0000956	76.12	gold quality
right uterine tube	UBERON:0001302	76.12	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	75.71	gold quality
ventricular zone	UBERON:0003053	75.11	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	3.10

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 3)

• Long non-coding RNA LINC01535 promotes cervical cancer progression via targeting the miR-214/EZH2 feedback loop. (PMID:31273925)
• LINC01535 promotes proliferation and inhibits apoptosis in esophageal squamous cell cancer by activating the JAK/STAT3 pathway. (PMID:32329845)
• lncRNA LINC01535 upregulates BMP2 expression levels to promote osteogenic differentiation via sponging miR36195p. (PMID:33174047)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.