LINC01537

Summary

LINC01537 (long intergenic non-protein coding RNA 1537, HGNC:51301) is a long non-coding RNA gene on chromosome 11q13.4.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:51301
Approved symbol	LINC01537
Name	long intergenic non-protein coding RNA 1537
Location	11q13.4
Locus type	RNA, long non-coding
Status	Approved
Aliases	h-Hilnc, RP11-169D4.1-001
Ensembl gene	ENSG00000227467
Ensembl biotype	lncRNA
Entrez	101928555
RNAcentral	URS00007E4869 — lncRNA, 2447 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 lncRNA

ENST00000450804

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000450804 — 2 exons

Exon	Start	End
ENSE00004219200	72571028	72573229
ENSE00004219201	72570645	72570907

Expression profiles

Bgee: expression breadth ubiquitous, 146 present calls, max score 77.26.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.3572 / max 37.2657, expressed in 91 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
115746	0.1553	57
115745	0.1193	36
115747	0.0826	34

Top tissues by expression

233 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	77.26	silver quality
spleen	UBERON:0002106	75.02	gold quality
omental fat pad	UBERON:0010414	67.79	gold quality
peritoneum	UBERON:0002358	67.71	gold quality
mucosa of stomach	UBERON:0001199	67.58	gold quality
adipose tissue of abdominal region	UBERON:0007808	66.64	gold quality
subcutaneous adipose tissue	UBERON:0002190	66.18	gold quality
colonic epithelium	UBERON:0000397	65.60	silver quality
cortical plate	UBERON:0005343	63.95	gold quality
adipose tissue	UBERON:0001013	63.35	gold quality
left uterine tube	UBERON:0001303	63.19	gold quality
ectocervix	UBERON:0012249	60.66	gold quality
sural nerve	UBERON:0015488	60.41	silver quality
hindlimb stylopod muscle	UBERON:0004252	60.31	gold quality
ganglionic eminence	UBERON:0004023	60.22	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	59.88	gold quality
body of uterus	UBERON:0009853	59.83	gold quality
lower esophagus muscularis layer	UBERON:0035833	59.62	gold quality
lower esophagus	UBERON:0013473	59.53	gold quality
muscle layer of sigmoid colon	UBERON:0035805	59.12	gold quality
right adrenal gland cortex	UBERON:0035827	59.05	gold quality
prefrontal cortex	UBERON:0000451	58.94	gold quality
right adrenal gland	UBERON:0001233	58.57	gold quality
heart left ventricle	UBERON:0002084	57.84	gold quality
left adrenal gland cortex	UBERON:0035825	57.79	gold quality
endocervix	UBERON:0000458	57.48	gold quality
lymph node	UBERON:0000029	57.32	gold quality
cardiac ventricle	UBERON:0002082	57.24	gold quality
left adrenal gland	UBERON:0001234	57.08	gold quality
smooth muscle tissue	UBERON:0001135	56.96	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.75

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Validation analysis confirmed the downregulation of LINC01537 in lung cancer. LINC01537 was observed to inhibit tumor growth and metastasis. It also increased cellular sensitivity to nilotinib. PDE2A (phosphodiesterase 2A) was further identified to be a target of LINC01537. (PMID:31374807)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.