LINC01550

Summary

LINC01550 (long intergenic non-protein coding RNA 1550, HGNC:20111) is a long non-coding RNA gene on chromosome 14q32.2.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:20111
Approved symbol	LINC01550
Name	long intergenic non-protein coding RNA 1550
Location	14q32.2
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000246223
Ensembl biotype	lncRNA
Entrez	388011
RNAcentral	URS00007BF2D9 — lncRNA, 1458 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 25 — 25 lncRNA

ENST00000499006, ENST00000502187, ENST00000512901, ENST00000554822, ENST00000556138, ENST00000556462, ENST00000652825, ENST00000662096, ENST00000736859, ENST00000736860, ENST00000736861, ENST00000736862, ENST00000736863, ENST00000736864, ENST00000736865, ENST00000736866, ENST00000736867, ENST00000736868, ENST00000736869, ENST00000736870, ENST00000736871, ENST00000736872, ENST00000736873, ENST00000736874, ENST00000736875

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000499006 — 3 exons

Exon	Start	End
ENSE00001986535	97969273	97969547
ENSE00004070558	97977977	97978136
ENSE00004070573	97924637	97926644

Expression profiles

Bgee: expression breadth ubiquitous, 174 present calls, max score 89.30.

FANTOM5 (CAGE): breadth broad, TPM avg 2.2907 / max 138.0785, expressed in 357 samples.

FANTOM5 promoters (5 alternative TSS)

Promoter ID	TPM avg	Samples expressed
144833	1.2585	267
144834	0.5932	229
144835	0.2766	124
144832	0.0953	45
207364	0.0671	40

Top tissues by expression

235 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
buccal mucosa cell	CL:0002336	89.30	gold quality
thymus	UBERON:0002370	86.58	gold quality
right uterine tube	UBERON:0001302	80.98	gold quality
skin of abdomen	UBERON:0001416	78.44	gold quality
lymph node	UBERON:0000029	77.68	gold quality
skin of leg	UBERON:0001511	77.11	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	76.44	gold quality
zone of skin	UBERON:0000014	75.57	gold quality
blood	UBERON:0000178	74.26	gold quality
sural nerve	UBERON:0015488	72.81	gold quality
fallopian tube	UBERON:0003889	72.56	gold quality
vermiform appendix	UBERON:0001154	72.31	gold quality
granulocyte	CL:0000094	72.21	gold quality
oviduct epithelium	UBERON:0004804	71.89	gold quality
bone marrow cell	CL:0002092	70.97	silver quality
tonsil	UBERON:0002372	70.14	gold quality
cortex of kidney	UBERON:0001225	69.91	gold quality
caecum	UBERON:0001153	69.72	gold quality
ventricular zone	UBERON:0003053	69.62	gold quality
ganglionic eminence	UBERON:0004023	68.90	gold quality
colonic epithelium	UBERON:0000397	68.67	silver quality
rectum	UBERON:0001052	68.37	gold quality
endothelial cell	CL:0000115	68.02	gold quality
descending thoracic aorta	UBERON:0002345	67.82	gold quality
gall bladder	UBERON:0002110	67.72	gold quality
heart left ventricle	UBERON:0002084	67.55	gold quality
adenohypophysis	UBERON:0002196	67.09	gold quality
adult mammalian kidney	UBERON:0000082	67.04	gold quality
calcaneal tendon	UBERON:0003701	66.97	gold quality
pituitary gland	UBERON:0000007	66.96	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	6.27

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 3)

• Elevated LINC01550 induces the apoptosis and cell cycle arrest of melanoma. (PMID:33609219)
• MIMT1 and LINC01550 are uncharted lncRNAs down-regulated in colorectal cancer. (PMID:36727289)
• Long noncoding RNA LINC01550 inhibits colorectal cancer malignancy by suppressing the Wnt/beta-catenin signaling pathway. (PMID:39041324)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.