LINC01554

Summary

LINC01554 (long intergenic non-protein coding RNA 1554, HGNC:24687) is a long non-coding RNA gene on chromosome 5q15.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:24687
Approved symbol	LINC01554
Name	long intergenic non-protein coding RNA 1554
Location	5q15
Locus type	RNA, long non-coding
Status	Approved
Aliases	FLJ38821, FIS
Ensembl gene	ENSG00000236882
Ensembl biotype	lncRNA
Entrez	202299
RNAcentral	URS000075DFD6 — lncRNA, 1931 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 15 — 15 lncRNA

ENST00000357880, ENST00000436592, ENST00000607856, ENST00000620167, ENST00000656444, ENST00000702482, ENST00000718060, ENST00000718061, ENST00000754941, ENST00000754942, ENST00000754943, ENST00000754944, ENST00000754945, ENST00000754946, ENST00000754947

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000357880 — 3 exons

Exon	Start	End
ENSE00001400257	95852232	95852714
ENSE00002019993	95856878	95856981
ENSE00004103415	95858804	95860141

Expression profiles

Bgee: expression breadth ubiquitous, 171 present calls, max score 96.99.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 1.0222 / max 290.9523, expressed in 104 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
57656	0.9609	83
57649	0.0553	15
57650	0.0060	2

Top tissues by expression

236 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right lobe of liver	UBERON:0001114	96.99	gold quality
liver	UBERON:0002107	93.69	gold quality
sperm	CL:0000019	85.43	gold quality
upper arm skin	UBERON:0004263	83.57	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	82.44	gold quality
gastrocnemius	UBERON:0001388	82.40	gold quality
spinal cord	UBERON:0002240	80.37	gold quality
saliva-secreting gland	UBERON:0001044	79.77	gold quality
minor salivary gland	UBERON:0001830	79.38	gold quality
muscle of leg	UBERON:0001383	78.88	gold quality
parotid gland	UBERON:0001831	78.14	gold quality
skin of leg	UBERON:0001511	76.28	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	76.22	gold quality
mouth mucosa	UBERON:0003729	75.48	gold quality
zone of skin	UBERON:0000014	73.84	gold quality
upper leg skin	UBERON:0004262	73.53	gold quality
epithelial cell of pancreas	CL:0000083	73.43	gold quality
skin of abdomen	UBERON:0001416	73.31	gold quality
nasal cavity mucosa	UBERON:0001826	72.11	gold quality
pancreatic ductal cell	CL:0002079	71.41	silver quality
kidney epithelium	UBERON:0004819	70.67	gold quality
adult mammalian kidney	UBERON:0000082	69.31	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	69.05	gold quality
cardiac muscle of right atrium	UBERON:0003379	68.83	gold quality
left ventricle myocardium	UBERON:0006566	68.50	gold quality
hindlimb stylopod muscle	UBERON:0004252	68.18	gold quality
nasal cavity epithelium	UBERON:0005384	68.03	gold quality
sural nerve	UBERON:0015488	67.91	gold quality
tibialis anterior	UBERON:0001385	67.63	silver quality
kidney	UBERON:0002113	67.32	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 5)

• Bioinformatics analysis of LINC01554 and its coexpressed genes in hepatocellular carcinoma. (PMID:33000250)
• Long-chain non-coding RNA LINC01554 promotes NGFR expression and inhibits cell proliferation, migration, and invasion in hepatocellular carcinoma by binding to microRNA-3681-3p. (PMID:33378013)
• Long Noncoding RNA LINC01554 as a Novel Biomarker for Diagnosis and Prognosis Prediction of Epithelial Ovarian Cancer. (PMID:34422133)
• Long Noncoding RNA LINC01554 Inhibits the Progression of NSCLC Progression by Functioning as a ceRNA for miR-1267 and Regulating ING3/Akt/mTOR Pathway. (PMID:35845928)
• Aberrant methylation-mediated downregulation of the LINC01554 gene accelerates the malignant progression and regulates the chemosensitivity of laryngeal squamous cell carcinoma. (PMID:35988928)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.