LINC01559

Summary

LINC01559 (long intergenic non-protein coding RNA 1559, HGNC:26598) is a long non-coding RNA gene on chromosome 12p13.1.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:26598
Approved symbol	LINC01559
Name	long intergenic non-protein coding RNA 1559
Location	12p13.1
Locus type	RNA, long non-coding
Status	Approved
Aliases	FLJ33810
Ensembl gene	ENSG00000180861
Ensembl biotype	lncRNA
Entrez	283422
RNAcentral	URS000075BA54 — lncRNA, 3202 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 5 — 5 lncRNA

ENST00000318426, ENST00000527705, ENST00000531049, ENST00000532841, ENST00000539026

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000318426 — 3 exons

Exon	Start	End
ENSE00001219237	13371089	13373438
ENSE00002148852	13376514	13376711
ENSE00002182264	13376224	13376425

Expression profiles

Bgee: expression breadth ubiquitous, 106 present calls, max score 95.44.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.0934 / max 21.8845, expressed in 39 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
129788	0.0509	25
129789	0.0396	19
129790	0.0028	2

Top tissues by expression

106 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
rectum	UBERON:0001052	95.44	gold quality
mucosa of transverse colon	UBERON:0004991	86.67	gold quality
gall bladder	UBERON:0002110	85.85	gold quality
colonic epithelium	UBERON:0000397	83.44	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	79.92	gold quality
transverse colon	UBERON:0001157	78.09	gold quality
tonsil	UBERON:0002372	77.44	gold quality
vermiform appendix	UBERON:0001154	76.38	gold quality
colon	UBERON:0001155	71.43	gold quality
esophagus mucosa	UBERON:0002469	71.40	gold quality
cortex of kidney	UBERON:0001225	70.03	gold quality
body of stomach	UBERON:0001161	68.29	gold quality
intestine	UBERON:0000160	67.49	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	67.20	gold quality
ectocervix	UBERON:0012249	66.76	gold quality
esophagus	UBERON:0001043	66.75	gold quality
stomach	UBERON:0000945	66.60	gold quality
duodenum	UBERON:0002114	66.51	gold quality
islet of Langerhans	UBERON:0000006	64.26	gold quality
mucosa of stomach	UBERON:0001199	62.47	gold quality
metanephros cortex	UBERON:0010533	62.08	gold quality
hindlimb stylopod muscle	UBERON:0004252	59.58	gold quality
pancreas	UBERON:0001264	58.97	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	58.70	gold quality
vagina	UBERON:0000996	58.25	gold quality
muscle tissue	UBERON:0002385	56.96	gold quality
multicellular organism	UBERON:0000468	56.71	gold quality
smooth muscle tissue	UBERON:0001135	55.93	gold quality
urinary bladder	UBERON:0001255	55.91	gold quality
small intestine	UBERON:0002108	55.50	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	4.04

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 4)

• LINC01559 accelerates pancreatic cancer cell proliferation and migration through YAP-mediated pathway. (PMID:31608998)
• Linc01559 Served as a Potential Oncogene and Promoted Resistance of Hepatocellular Carcinoma to Oxaliplatin by Directly Sponging miR-6783-3p. (PMID:32698745)
• Long non-coding RNA LINC01559 serves as a competing endogenous RNA accelerating triple-negative breast cancer progression. (PMID:35715331)
• FTO-mediated epigenetic upregulation of LINC01559 confers cell resistance to docetaxel in breast carcinoma by suppressing miR-1343-3p. (PMID:37584416)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.