LINC01579

Summary

LINC01579 (long intergenic non-protein coding RNA 1579, HGNC:27519) is a long non-coding RNA gene on chromosome 15q26.1-q26.2.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:27519
Approved symbol	LINC01579
Name	long intergenic non-protein coding RNA 1579
Location	15q26.1-q26.2
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000258754
Ensembl biotype	lncRNA
Entrez	283682
RNAcentral	URS0000A7645F — lncRNA, 793 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 27 — 27 lncRNA

ENST00000553477, ENST00000553818, ENST00000554261, ENST00000555023, ENST00000555772, ENST00000556447, ENST00000556928, ENST00000557481, ENST00000557715, ENST00000557777, ENST00000653341, ENST00000653794, ENST00000657935, ENST00000658920, ENST00000660982, ENST00000661055, ENST00000664929, ENST00000667659, ENST00000669397, ENST00000766606, ENST00000766607, ENST00000766608, ENST00000766609, ENST00000766610, ENST00000766611, ENST00000766612, ENST00000766613

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000553477 — 2 exons

Exon	Start	End
ENSE00002488727	93852818	93852981
ENSE00004125438	93837611	93837888

Expression profiles

Bgee: expression breadth ubiquitous, 155 present calls, max score 81.65.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.3869 / max 42.0190, expressed in 163 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
151669	0.2041	110
151667	0.1155	31
151668	0.0673	30

Top tissues by expression

243 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	81.65	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	80.81	gold quality
muscle layer of sigmoid colon	UBERON:0035805	75.03	gold quality
smooth muscle tissue	UBERON:0001135	74.41	gold quality
right testis	UBERON:0004534	74.25	gold quality
left testis	UBERON:0004533	72.39	gold quality
hypothalamus	UBERON:0001898	72.09	gold quality
body of uterus	UBERON:0009853	71.55	gold quality
colonic epithelium	UBERON:0000397	71.08	gold quality
testis	UBERON:0000473	70.74	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	70.54	gold quality
sural nerve	UBERON:0015488	69.95	gold quality
spinal cord	UBERON:0002240	67.80	gold quality
bone marrow cell	CL:0002092	67.61	silver quality
anterior cingulate cortex	UBERON:0009835	67.54	gold quality
monocyte	CL:0000576	67.36	gold quality
substantia nigra	UBERON:0002038	66.39	gold quality
cortical plate	UBERON:0005343	66.38	gold quality
ventricular zone	UBERON:0003053	65.47	gold quality
lower esophagus muscularis layer	UBERON:0035833	64.79	gold quality
lower esophagus	UBERON:0013473	64.76	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	64.23	gold quality
blood	UBERON:0000178	64.18	gold quality
left uterine tube	UBERON:0001303	64.08	gold quality
gall bladder	UBERON:0002110	63.99	gold quality
ectocervix	UBERON:0012249	63.79	gold quality
colon	UBERON:0001155	63.33	gold quality
midbrain	UBERON:0001891	63.25	gold quality
mucosa of stomach	UBERON:0001199	62.97	gold quality
large intestine	UBERON:0000059	62.51	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	5.79

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• the results of this study verified that LINC01579 modulated cell proliferation and cell apoptosis in Glioblastoma by competitively binding with miR-139-5p to regulate EIF4G2, which provided a new clue to figure out potential therapy for patients suffered from Glioblastoma. (PMID:31187495)
• LINC01579-204 involved in the development of Hirschsprung’s disease maybe by regulating the expression of miR-203a-3p and NEFL. (PMID:37923059)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.