LINC01592

Summary

LINC01592 (long intergenic non-protein coding RNA 1592, HGNC:51557) is a long non-coding RNA gene on chromosome 8q13.2.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:51557
Approved symbol	LINC01592
Name	long intergenic non-protein coding RNA 1592
Location	8q13.2
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000253658
Ensembl biotype	lncRNA
Entrez	100505718
RNAcentral	URS00000EEF24 — lncRNA, 2367 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 22 — 22 lncRNA

ENST00000517925, ENST00000518540, ENST00000519062, ENST00000524286, ENST00000657605, ENST00000657671, ENST00000662535, ENST00000662861, ENST00000663873, ENST00000663915, ENST00000663971, ENST00000664220, ENST00000665853, ENST00000669481, ENST00000670857, ENST00000836182, ENST00000836183, ENST00000836184, ENST00000836185, ENST00000836186, ENST00000836187, ENST00000836188

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000517925 — 3 exons

Exon	Start	End
ENSE00002111208	68924387	68924495
ENSE00002111806	68959306	68959649
ENSE00003858089	68912887	68913540

Expression profiles

Bgee: expression breadth broad, 86 present calls, max score 87.59.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.1987 / max 24.0170, expressed in 56 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
93469	0.1656	51
93468	0.0331	13

Top tissues by expression

186 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	87.59	gold quality
buccal mucosa cell	CL:0002336	75.81	gold quality
right coronary artery	UBERON:0001625	64.28	gold quality
tibial artery	UBERON:0007610	62.93	gold quality
popliteal artery	UBERON:0002250	62.92	gold quality
right testis	UBERON:0004534	60.87	gold quality
left testis	UBERON:0004533	60.69	gold quality
aorta	UBERON:0000947	60.56	gold quality
testis	UBERON:0000473	59.49	gold quality
ascending aorta	UBERON:0001496	58.02	gold quality
left coronary artery	UBERON:0001626	57.78	gold quality
thoracic aorta	UBERON:0001515	57.65	gold quality
coronary artery	UBERON:0001621	57.31	gold quality
cortical plate	UBERON:0005343	54.12	silver quality
stromal cell of endometrium	CL:0002255	53.78	silver quality
calcaneal tendon	UBERON:0003701	52.30	silver quality
descending thoracic aorta	UBERON:0002345	51.60	gold quality
monocyte	CL:0000576	51.12	silver quality
muscle of leg	UBERON:0001383	48.42	silver quality
heart	UBERON:0000948	48.17	gold quality
subcutaneous adipose tissue	UBERON:0002190	47.10	gold quality
lymph node	UBERON:0000029	46.95	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	46.47	silver quality
cortex of kidney	UBERON:0001225	46.24	silver quality
islet of Langerhans	UBERON:0000006	46.13	silver quality
anatomical system	UBERON:0000467	45.87	gold quality
gastrocnemius	UBERON:0001388	45.81	silver quality
gall bladder	UBERON:0002110	45.74	silver quality
right ovary	UBERON:0002118	45.67	gold quality
multicellular organism	UBERON:0000468	45.56	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	3.75

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Role of LINC01592 in TGF-beta1-induced epithelial-mesenchymal transition of retinal pigment epithelial cells. (PMID:34032608)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.