LINC01594

Summary

LINC01594 (long intergenic non-protein coding RNA 1594, HGNC:51584) is a long non-coding RNA gene on chromosome 2q12.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:51584
Approved symbol	LINC01594
Name	long intergenic non-protein coding RNA 1594
Location	2q12.3
Locus type	RNA, long non-coding
Status	Approved
Aliases	TCONS_l2_00015893
Ensembl gene	ENSG00000225328
Ensembl biotype	lncRNA
Entrez	102724774
RNAcentral	URS00005ED704 — lncRNA, 611 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 3 — 3 lncRNA

ENST00000445083, ENST00000666270, ENST00000669479

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000445083 — 5 exons

Exon	Start	End
ENSE00001594974	108169498	108169586
ENSE00001624043	108179154	108179281
ENSE00001703703	108217695	108217886
ENSE00001753912	108167126	108167769
ENSE00001759154	108184458	108184682

Expression profiles

Bgee: expression breadth broad, 96 present calls, max score 85.42.

Top tissues by expression

96 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	85.42	gold quality
colonic epithelium	UBERON:0000397	67.27	silver quality
adult mammalian kidney	UBERON:0000082	62.70	gold quality
kidney	UBERON:0002113	60.37	gold quality
left testis	UBERON:0004533	57.27	gold quality
testis	UBERON:0000473	57.06	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	56.78	gold quality
right testis	UBERON:0004534	56.49	gold quality
body of stomach	UBERON:0001161	55.80	gold quality
prostate gland	UBERON:0002367	55.68	gold quality
cortex of kidney	UBERON:0001225	55.42	gold quality
hindlimb stylopod muscle	UBERON:0004252	55.36	gold quality
stomach	UBERON:0000945	55.03	gold quality
metanephros cortex	UBERON:0010533	54.46	gold quality
liver	UBERON:0002107	54.09	gold quality
endometrium	UBERON:0001295	53.34	gold quality
blood	UBERON:0000178	53.04	silver quality
stromal cell of endometrium	CL:0002255	52.74	silver quality
fundus of stomach	UBERON:0001160	52.04	gold quality
right lobe of liver	UBERON:0001114	51.12	silver quality
body of pancreas	UBERON:0001150	50.31	gold quality
rectum	UBERON:0001052	50.13	gold quality
pancreas	UBERON:0001264	50.12	gold quality
muscle of leg	UBERON:0001383	49.74	gold quality
prefrontal cortex	UBERON:0000451	47.90	gold quality
gastrocnemius	UBERON:0001388	47.85	gold quality
gall bladder	UBERON:0002110	47.80	gold quality
multicellular organism	UBERON:0000468	47.76	gold quality
heart left ventricle	UBERON:0002084	47.63	gold quality
small intestine	UBERON:0002108	47.32	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.79

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Long noncoding RNA LINC01594 inhibits the CELF6-mediated splicing of oncogenic CD44 variants to promote colorectal cancer metastasis. (PMID:37452042)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.