LINC01599

Summary

LINC01599 (long intergenic non-protein coding RNA 1599, HGNC:27285) is a long non-coding RNA gene on chromosome 14q21.3.

At a glance

• Clinical variants (ClinVar): 6 total

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:27285
Approved symbol	LINC01599
Name	long intergenic non-protein coding RNA 1599
Location	14q21.3
Locus type	RNA, long non-coding
Status	Approved
Entrez	196913

Gene structure

Transcript identifiers

Ensembl transcripts: 0

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

None — 0 exons

Expression profiles

Top tissues by expression

0 total, by Bgee expression score (0-100, higher = more expressed):

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Protein identifiers

Putative uncharacterized protein encoded by LINC01599 — Q8WXQ3 (reviewed: Q8WXQ3)

All UniProt accessions (0):

RefSeq proteins (0): (*=MANE)

Domains & families (InterPro)

UniProt features (1 total): chain 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8WXQ3-F1	30.03	0.00

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 0 (showing top):

GO Biological Process (0):

GO Molecular Function (0):

GO Cellular Component (0):

Protein interactions and networks

STRING

0 interactions, top by confidence (×1000):

IntAct

0 interactions, top by confidence:

BioGRID (3): C14orf183 (Synthetic Lethality), C14orf183 (Affinity Capture-MS), C14orf183 (Cross-Linking-MS (XL-MS))

ESM2 similar proteins: A0A1B0GTK4, A0JNL8, A2RUT3, A4D1N5, A4D250, B1ANY3, C0HMD7, F1MQW7, F2Z3F1, J3KSC0, O14603, O95411, P0C092, P0DMR3, P37200, P47939, P47940, P69615, Q0VFX4, Q14695, Q32KZ5, Q3C1V9, Q4G0G2, Q4R3X9, Q52M75, Q53S99, Q5SR53, Q5SWW7, Q5T6R2, Q5W5W9, Q66669, Q66HF0, Q6AWC8, Q6DGF6, Q6ZP68, Q6ZV80, Q6ZVU0, Q7L4S7, Q7Z4H9, Q8N2C9

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

6 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

0 predictions. Top by Δscore:

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000030067 (14:50030756 A>C), RS1000062717 (14:50076785 C>A,T), RS1000092491 (14:50068735 A>AG), RS1000103200 (14:50031147 C>G,T), RS1000130264 (14:50097026 A>G), RS1000137607 (14:50052692 T>C), RS1000148274 (14:50068302 C>G), RS1000190316 (14:50053040 G>A), RS1000216488 (14:50008391 G>A), RS1000217462 (14:50054255 G>C,T), RS1000323630 (14:50023694 G>A,C), RS1000340106 (14:50037374 G>A), RS1000396999 (14:50048124 G>A), RS1000447374 (14:50042247 T>A), RS1000451870 (14:50075212 G>A)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 0 entries

CTD chemical–gene interactions

5 total (human), top 5 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Benzo(a)pyrene	affects methylation, increases methylation	2
aflatoxin B2	increases methylation	1
(+)-JQ1 compound	increases expression	1
Smoke	decreases expression	1
Aflatoxin B1	decreases methylation	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.