LINC01608

Summary

LINC01608 (long intergenic non-protein coding RNA 1608, HGNC:51662) is a long non-coding RNA gene on chromosome 8q23.2.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:51662
Approved symbol	LINC01608
Name	long intergenic non-protein coding RNA 1608
Location	8q23.2
Locus type	RNA, long non-coding
Status	Approved
Aliases	TCONS_00015136
Ensembl gene	ENSG00000253877
Ensembl biotype	lncRNA
Entrez	101927459
RNAcentral	URS00007E3D42 — lncRNA, 585 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 32 — 32 lncRNA

ENST00000523557, ENST00000524283, ENST00000653924, ENST00000657323, ENST00000657532, ENST00000658028, ENST00000658081, ENST00000658119, ENST00000658508, ENST00000658597, ENST00000658733, ENST00000659834, ENST00000660015, ENST00000660667, ENST00000661561, ENST00000661954, ENST00000662310, ENST00000663408, ENST00000663666, ENST00000664704, ENST00000665011, ENST00000665803, ENST00000667145, ENST00000668858, ENST00000668936, ENST00000668956, ENST00000669698, ENST00000669744, ENST00000669893, ENST00000669997, ENST00000670392, ENST00000671489

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000523557 — 5 exons

Exon	Start	End
ENSE00002092223	111027306	111027401
ENSE00002098898	111014904	111015032
ENSE00002120109	110982983	110983140
ENSE00002130651	111003414	111003450
ENSE00002139216	111005530	111005649

Expression profiles

Bgee: expression breadth ubiquitous, 130 present calls, max score 95.73.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 1.0685 / max 100.4753, expressed in 141 samples.

FANTOM5 promoters (5 alternative TSS)

Promoter ID	TPM avg	Samples expressed
94439	0.6496	76
94442	0.2932	64
94441	0.0713	41
94438	0.0391	23
94440	0.0152	11

Top tissues by expression

130 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
corpus callosum	UBERON:0002336	95.73	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	83.13	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	82.58	gold quality
Ammon’s horn	UBERON:0001954	81.05	gold quality
putamen	UBERON:0001874	80.91	gold quality
substantia nigra	UBERON:0002038	79.97	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	79.72	gold quality
sural nerve	UBERON:0015488	79.30	gold quality
amygdala	UBERON:0001876	78.79	gold quality
temporal lobe	UBERON:0001871	78.48	gold quality
primary visual cortex	UBERON:0002436	77.81	gold quality
caudate nucleus	UBERON:0001873	76.19	gold quality
Brodmann (1909) area 9	UBERON:0013540	75.76	gold quality
colonic epithelium	UBERON:0000397	73.72	gold quality
hypothalamus	UBERON:0001898	72.75	gold quality
cerebral cortex	UBERON:0000956	72.74	gold quality
nucleus accumbens	UBERON:0001882	72.32	gold quality
prefrontal cortex	UBERON:0000451	72.26	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	72.17	gold quality
frontal cortex	UBERON:0001870	71.84	gold quality
superior frontal gyrus	UBERON:0002661	71.43	gold quality
brain	UBERON:0000955	71.26	gold quality
right frontal lobe	UBERON:0002810	71.06	gold quality
bone marrow cell	CL:0002092	69.28	silver quality
anterior cingulate cortex	UBERON:0009835	67.55	gold quality
cortical plate	UBERON:0005343	65.53	gold quality
skeletal muscle tissue	UBERON:0001134	65.11	gold quality
stromal cell of endometrium	CL:0002255	64.03	gold quality
muscle tissue	UBERON:0002385	63.74	gold quality
bone marrow	UBERON:0002371	63.19	silver quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-HCAD-35	yes	84.90
E-ANND-3	no	2.27

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• LINC01608 activated by YY1 facilitate hepatocellular carcinoma progression by modulating the EGFR/ERK axis. (PMID:36385489)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.