LINC01614

Summary

LINC01614 (long intergenic non-protein coding RNA 1614, HGNC:51847) is a long non-coding RNA gene on chromosome 2q35.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:51847
Approved symbol	LINC01614
Name	long intergenic non-protein coding RNA 1614
Location	2q35
Locus type	RNA, long non-coding
Status	Approved
Aliases	LCAL4, TCONS_00003105
Ensembl gene	ENSG00000230838
Ensembl biotype	lncRNA
Entrez	105373869
RNAcentral	URS00008E3A62 — lncRNA, 2180 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 4 — 4 lncRNA

ENST00000415479, ENST00000768239, ENST00000768240, ENST00000768241

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000415479 — 2 exons

Exon	Start	End
ENSE00004128399	215718997	215720947
ENSE00004128405	215717920	215718262

Expression profiles

Bgee: expression breadth ubiquitous, 107 present calls, max score 83.66.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.2631 / max 38.4651, expressed in 87 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
25176	0.2631	87

Top tissues by expression

107 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	83.66	gold quality
islet of Langerhans	UBERON:0000006	73.27	gold quality
placenta	UBERON:0001987	68.86	gold quality
stromal cell of endometrium	CL:0002255	66.31	gold quality
descending thoracic aorta	UBERON:0002345	65.85	gold quality
gall bladder	UBERON:0002110	65.33	gold quality
right coronary artery	UBERON:0001625	63.80	gold quality
ganglionic eminence	UBERON:0004023	62.37	gold quality
left coronary artery	UBERON:0001626	62.31	gold quality
smooth muscle tissue	UBERON:0001135	62.20	gold quality
popliteal artery	UBERON:0002250	59.63	gold quality
tibial artery	UBERON:0007610	59.60	gold quality
thoracic aorta	UBERON:0001515	59.22	gold quality
ascending aorta	UBERON:0001496	58.85	gold quality
urinary bladder	UBERON:0001255	58.45	gold quality
lymph node	UBERON:0000029	57.94	gold quality
endometrium	UBERON:0001295	56.76	gold quality
left uterine tube	UBERON:0001303	56.66	gold quality
fallopian tube	UBERON:0003889	55.93	gold quality
liver	UBERON:0002107	55.38	gold quality
prefrontal cortex	UBERON:0000451	54.59	gold quality
heart left ventricle	UBERON:0002084	54.11	gold quality
apex of heart	UBERON:0002098	53.87	gold quality
myometrium	UBERON:0001296	53.54	gold quality
monocyte	CL:0000576	53.29	silver quality
heart	UBERON:0000948	53.20	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	52.75	gold quality
cortex of kidney	UBERON:0001225	51.80	gold quality
vermiform appendix	UBERON:0001154	51.63	gold quality
lower esophagus	UBERON:0013473	51.37	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.96

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 6)

• It was shown that LINC01614 promoted the expression of FOXP1 by inhibiting miR-217, which ultimately stimulated the development of lung adenocarcinoma. (PMID:29934982)
• LINC01614 promotes osteosarcoma progression via miR-520a-3p/SNX3 axis. (PMID:33753211)
• Risk SNP-mediated LINC01614 upregulation drives head and neck squamous cell carcinoma progression via PI3K/AKT signaling pathway. (PMID:35687049)
• Long noncoding RNA 01614 hyperactivates WNT/betacatenin signaling to promote pancreatic cancer progression by suppressing GSK3beta. (PMID:35929518)
• Long Noncoding RNA LINC01614 is a Diagnostic and Prognostic Marker for Breast Cancer. (PMID:37024438)
• LINC01614 activated by SP1 promoted malignant behavior of triple-negative breast cancer cells via the WNT/b-Catenin signaling pathway. (PMID:39419019)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.