LINC01619

Summary

LINC01619 (long intergenic non-protein coding RNA 1619, HGNC:27409) is a long non-coding RNA gene on chromosome 12q21.33.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:27409
Approved symbol	LINC01619
Name	long intergenic non-protein coding RNA 1619
Location	12q21.33
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000257242
Ensembl biotype	lncRNA
Entrez	256021
RNAcentral	URS00008E3966 — lncRNA, 2460 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 22 — 21 lncRNA, 1 retained_intron

ENST00000546975, ENST00000548552, ENST00000549802, ENST00000551306, ENST00000551563, ENST00000551764, ENST00000551843, ENST00000552106, ENST00000552277, ENST00000553207, ENST00000664336, ENST00000671521, ENST00000689659, ENST00000775490, ENST00000775491, ENST00000775492, ENST00000775493, ENST00000775494, ENST00000775495, ENST00000775496, ENST00000775497, ENST00000775498

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000546975 — 5 exons

Exon	Start	End
ENSE00002367249	92142607	92142668
ENSE00003602345	91987556	91987643
ENSE00003647209	91989097	91989193
ENSE00003756366	91985778	91986697
ENSE00003760054	91993370	91993529

Expression profiles

Bgee: expression breadth ubiquitous, 154 present calls, max score 82.21.

FANTOM5 (CAGE): breadth broad, TPM avg 1.7307 / max 139.5023, expressed in 235 samples.

FANTOM5 promoters (7 alternative TSS)

Promoter ID	TPM avg	Samples expressed
132615	0.6855	121
132613	0.4347	85
132610	0.2087	70
132616	0.1717	78
132612	0.1196	42
132611	0.0679	28
132614	0.0426	25

Top tissues by expression

241 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
monocyte	CL:0000576	82.21	gold quality
leukocyte	CL:0000738	81.32	gold quality
bone marrow cell	CL:0002092	80.20	gold quality
cerebellar hemisphere	UBERON:0002245	77.27	gold quality
cerebellar cortex	UBERON:0002129	77.19	gold quality
right hemisphere of cerebellum	UBERON:0014890	76.82	gold quality
sural nerve	UBERON:0015488	76.06	gold quality
calcaneal tendon	UBERON:0003701	75.99	gold quality
cerebellum	UBERON:0002037	74.95	gold quality
left uterine tube	UBERON:0001303	73.68	gold quality
granulocyte	CL:0000094	73.05	gold quality
spleen	UBERON:0002106	72.61	gold quality
skin of abdomen	UBERON:0001416	72.53	gold quality
adrenal tissue	UBERON:0018303	71.35	gold quality
hindlimb stylopod muscle	UBERON:0004252	71.00	gold quality
lymph node	UBERON:0000029	70.60	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	70.48	gold quality
right lung	UBERON:0002167	70.47	gold quality
small intestine Peyer’s patch	UBERON:0003454	70.11	gold quality
islet of Langerhans	UBERON:0000006	70.09	gold quality
skin of leg	UBERON:0001511	69.85	gold quality
upper lobe of left lung	UBERON:0008952	69.68	gold quality
mucosa of stomach	UBERON:0001199	69.11	gold quality
vermiform appendix	UBERON:0001154	68.14	gold quality
upper lobe of lung	UBERON:0008948	67.50	gold quality
pancreas	UBERON:0001264	67.45	gold quality
zone of skin	UBERON:0000014	67.41	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	67.34	gold quality
body of pancreas	UBERON:0001150	66.99	gold quality
small intestine	UBERON:0002108	66.29	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	3.74

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• study demonstrates that LINC01619 functions as a competing endogenous RNA and regulates miR-27a/FOXO1-mediated ER stress and podocyte injury in diabetic nephropathy (PMID:29334763)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.