LINC01627

Summary

LINC01627 (long intergenic non-protein coding RNA 1627, HGNC:52258) is a long non-coding RNA gene on chromosome 9p13.2.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:52258
Approved symbol	LINC01627
Name	long intergenic non-protein coding RNA 1627
Location	9p13.2
Locus type	RNA, long non-coding
Status	Approved
Aliases	RP11-397D12.4
Ensembl gene	ENSG00000224648
Ensembl biotype	lncRNA
Entrez	105376036
RNAcentral	URS00001428C6 — lncRNA, 243 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 lncRNA

ENST00000452923

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000452923 — 2 exons

Exon	Start	End
ENSE00001744178	37384306	37384434
ENSE00001764516	37383178	37383291

Expression profiles

Bgee: expression breadth broad, 77 present calls, max score 73.08.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.0069 / max 9.2065, expressed in 2 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
100724	0.0069	2

Top tissues by expression

77 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
lymph node	UBERON:0000029	73.08	gold quality
tonsil	UBERON:0002372	69.52	gold quality
bone marrow	UBERON:0002371	68.14	gold quality
monocyte	CL:0000576	67.70	gold quality
vermiform appendix	UBERON:0001154	64.73	gold quality
amygdala	UBERON:0001876	64.47	gold quality
saliva-secreting gland	UBERON:0001044	63.14	gold quality
liver	UBERON:0002107	62.61	gold quality
islet of Langerhans	UBERON:0000006	62.00	gold quality
blood	UBERON:0000178	60.80	gold quality
prefrontal cortex	UBERON:0000451	59.89	gold quality
gastrocnemius	UBERON:0001388	59.48	gold quality
right ovary	UBERON:0002118	59.02	gold quality
body of pancreas	UBERON:0001150	57.36	gold quality
adrenal tissue	UBERON:0018303	56.26	gold quality
lower esophagus muscularis layer	UBERON:0035833	55.70	gold quality
tibial artery	UBERON:0007610	55.50	gold quality
calcaneal tendon	UBERON:0003701	55.12	gold quality
ascending aorta	UBERON:0001496	55.04	gold quality
upper lobe of left lung	UBERON:0008952	54.06	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	53.97	gold quality
left coronary artery	UBERON:0001626	53.91	gold quality
substantia nigra	UBERON:0002038	53.67	gold quality
Brodmann (1909) area 9	UBERON:0013540	53.66	gold quality
body of stomach	UBERON:0001161	53.55	gold quality
left adrenal gland	UBERON:0001234	53.22	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	53.14	gold quality
left adrenal gland cortex	UBERON:0035825	52.98	gold quality
adipose tissue	UBERON:0001013	52.95	gold quality
Ammon’s horn	UBERON:0001954	52.82	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.82

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Results show that RP11-397D12.4, AC007403.1, and ERICH1-AS1 LncRNA expression are up-regulated in non-small-cell lung cancer (NSCLC) and may be potential biomarkers for predicting the tumorigenesis of NSCLC in the future. (PMID:26393913)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.