LINC01638

Summary

LINC01638 (long intergenic non-protein coding RNA 1638, HGNC:52425) is a long non-coding RNA gene on chromosome 22q12.1.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:52425
Approved symbol	LINC01638
Name	long intergenic non-protein coding RNA 1638
Location	22q12.1
Locus type	RNA, long non-coding
Status	Approved
Aliases	lncRNA4114
Ensembl gene	ENSG00000233521
Ensembl biotype	lncRNA
Entrez	105372978
RNAcentral	URS0002123252 — lncRNA, 588 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 12 — 12 lncRNA

ENST00000418271, ENST00000444114, ENST00000650737, ENST00000659538, ENST00000660027, ENST00000690524, ENST00000805083, ENST00000805084, ENST00000805085, ENST00000805086, ENST00000805087, ENST00000805088

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000418271 — 3 exons

Exon	Start	End
ENSE00001614165	27224230	27224308
ENSE00004197048	27224523	27224679
ENSE00004197051	27223295	27223634

Expression profiles

Bgee: expression breadth ubiquitous, 138 present calls, max score 79.60.

FANTOM5 (CAGE): breadth broad, TPM avg 3.1122 / max 77.6220, expressed in 593 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
193451	2.0117	490
193450	0.8702	372
193449	0.2303	139

Top tissues by expression

231 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	79.60	silver quality
left ovary	UBERON:0002119	72.58	gold quality
right ovary	UBERON:0002118	70.64	gold quality
colonic epithelium	UBERON:0000397	69.19	silver quality
ovary	UBERON:0000992	66.92	gold quality
ganglionic eminence	UBERON:0004023	66.51	gold quality
omental fat pad	UBERON:0010414	66.17	gold quality
peritoneum	UBERON:0002358	66.10	gold quality
adipose tissue of abdominal region	UBERON:0007808	64.76	gold quality
gall bladder	UBERON:0002110	64.13	gold quality
hindlimb stylopod muscle	UBERON:0004252	63.33	gold quality
lower esophagus	UBERON:0013473	62.16	gold quality
lower esophagus muscularis layer	UBERON:0035833	62.15	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	60.01	gold quality
vermiform appendix	UBERON:0001154	59.77	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	59.64	gold quality
tendon of biceps brachii	UBERON:0008188	59.39	gold quality
left uterine tube	UBERON:0001303	59.33	gold quality
adrenal tissue	UBERON:0018303	58.98	gold quality
calcaneal tendon	UBERON:0003701	56.90	gold quality
tendon	UBERON:0000043	56.87	silver quality
body of uterus	UBERON:0009853	56.74	gold quality
smooth muscle tissue	UBERON:0001135	56.66	gold quality
esophagus	UBERON:0001043	56.52	gold quality
islet of Langerhans	UBERON:0000006	56.11	gold quality
tibial nerve	UBERON:0001323	55.90	gold quality
monocyte	CL:0000576	55.63	gold quality
caecum	UBERON:0001153	55.47	gold quality
mucosa of transverse colon	UBERON:0004991	55.19	gold quality
muscle layer of sigmoid colon	UBERON:0035805	54.76	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.09

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 5)

• Linc01638 was over-expressed in HER2-positive breast cancer cells and tumor tissues. Linc01638 plays a crucial role in HER2-positive breast cancer, especially in tumor growth and metastasis. (PMID:29992881)
• SP1-regulated LINC01638 promotes proliferation and inhibits apoptosis in non-small cell lung cancer. (PMID:31696478)
• It is concluded that LINC01638 lncRNA may be involved in the migration and invasion of pancreatic ductal adenocarcinoma cells via regulation of TGFbeta1. (PMID:31702018)
• Long noncoding RNA LINC01638 contributes to laryngeal squamous cell cancer progression by modulating miR-523-5p/BATF3 axis. (PMID:33714208)
• ETS like-1 protein ELK1-induced lncRNA LINC01638 accelerates the progression of papillary thyroid cancer by regulating Axin2 through Wnt/beta-catenin signaling pathway. (PMID:34281460)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.