LINC01672

Summary

LINC01672 (long intergenic non-protein coding RNA 1672, HGNC:52460) is a long non-coding RNA gene on chromosome 1p36.31.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:52460
Approved symbol	LINC01672
Name	long intergenic non-protein coding RNA 1672
Location	1p36.31
Locus type	RNA, long non-coding
Status	Approved
Aliases	NMR
Ensembl gene	ENSG00000228750
Ensembl biotype	lncRNA
Entrez	100505887
RNAcentral	URS000075CC1C — lncRNA, 411 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 8 — 8 lncRNA

ENST00000414210, ENST00000421469, ENST00000432429, ENST00000635029, ENST00000635092, ENST00000654537, ENST00000826301, ENST00000826302

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000414210 — 2 exons

Exon	Start	End
ENSE00004237032	6729720	6730012
ENSE00004237033	6724626	6724850

Expression profiles

Bgee: expression breadth ubiquitous, 107 present calls, max score 80.12.

Top tissues by expression

107 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	80.12	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	78.82	silver quality
sural nerve	UBERON:0015488	74.19	gold quality
tonsil	UBERON:0002372	72.86	gold quality
right testis	UBERON:0004534	70.23	gold quality
testis	UBERON:0000473	69.15	gold quality
left testis	UBERON:0004533	68.64	gold quality
ventricular zone	UBERON:0003053	66.32	gold quality
skeletal muscle tissue	UBERON:0001134	62.32	gold quality
cortical plate	UBERON:0005343	61.43	gold quality
stromal cell of endometrium	CL:0002255	57.87	gold quality
muscle tissue	UBERON:0002385	56.06	gold quality
liver	UBERON:0002107	55.47	gold quality
ganglionic eminence	UBERON:0004023	54.77	silver quality
adrenal tissue	UBERON:0018303	54.47	gold quality
monocyte	CL:0000576	53.83	gold quality
bone marrow	UBERON:0002371	52.74	silver quality
endometrium	UBERON:0001295	52.56	silver quality
blood	UBERON:0000178	52.01	gold quality
islet of Langerhans	UBERON:0000006	51.00	gold quality
adult mammalian kidney	UBERON:0000082	50.82	gold quality
lymph node	UBERON:0000029	50.52	silver quality
corpus callosum	UBERON:0002336	50.44	gold quality
right coronary artery	UBERON:0001625	50.43	gold quality
left lobe of thyroid gland	UBERON:0001120	50.22	gold quality
thyroid gland	UBERON:0002046	50.08	gold quality
muscle of leg	UBERON:0001383	50.07	gold quality
gastrocnemius	UBERON:0001388	49.69	gold quality
kidney	UBERON:0002113	49.64	gold quality
urinary bladder	UBERON:0001255	49.48	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	3.26

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Study identified a novel NSUN2 methylated lncRNA (NMR), which was significantly upregulated in esophageal squamous cell carcinoma (ESCC), functioned as a key regulator of ESCC tumor metastasis and drug resistance. NMR could directly bind to chromatin regulator BPTF, and potentially promote MMP3 and MMP10 expression by ERK1/2 pathway through recruiting BPTF to chromatin. (PMID:29763634)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.