LINC01686

Summary

LINC01686 (long intergenic non-protein coding RNA 1686, HGNC:27643) is a long non-coding RNA gene on chromosome 1q25.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:27643
Approved symbol	LINC01686
Name	long intergenic non-protein coding RNA 1686
Location	1q25.3
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000261504
Ensembl biotype	lncRNA
Entrez	284648
RNAcentral	URS000075DC66 — lncRNA, 1504 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 lncRNA

ENST00000566297

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000566297 — 1 exons

Exon	Start	End
ENSE00002594015	182615254	182616629

Expression profiles

Bgee: expression breadth ubiquitous, 139 present calls, max score 87.31.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.2290 / max 10.5370, expressed in 97 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
7042	0.1816	71
7043	0.0474	19

Top tissues by expression

231 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	87.31	gold quality
cortical plate	UBERON:0005343	63.32	gold quality
cartilage tissue	UBERON:0002418	62.06	silver quality
hindlimb stylopod muscle	UBERON:0004252	61.51	gold quality
monocyte	CL:0000576	57.50	gold quality
myocardium	UBERON:0002349	57.36	gold quality
ganglionic eminence	UBERON:0004023	57.29	gold quality
descending thoracic aorta	UBERON:0002345	56.24	gold quality
right lobe of liver	UBERON:0001114	55.90	gold quality
adenohypophysis	UBERON:0002196	54.97	gold quality
islet of Langerhans	UBERON:0000006	54.96	gold quality
calcaneal tendon	UBERON:0003701	54.87	gold quality
tendon of biceps brachii	UBERON:0008188	54.44	gold quality
tendon	UBERON:0000043	54.40	silver quality
ascending aorta	UBERON:0001496	54.07	gold quality
thoracic aorta	UBERON:0001515	54.03	gold quality
left uterine tube	UBERON:0001303	53.89	gold quality
smooth muscle tissue	UBERON:0001135	52.86	gold quality
lymph node	UBERON:0000029	52.25	gold quality
aorta	UBERON:0000947	52.22	gold quality
muscle of leg	UBERON:0001383	51.66	gold quality
prefrontal cortex	UBERON:0000451	51.51	gold quality
gall bladder	UBERON:0002110	51.43	gold quality
putamen	UBERON:0001874	51.42	gold quality
omental fat pad	UBERON:0010414	51.26	gold quality
peritoneum	UBERON:0002358	51.23	gold quality
left coronary artery	UBERON:0001626	51.16	gold quality
gastrocnemius	UBERON:0001388	51.00	gold quality
popliteal artery	UBERON:0002250	50.89	gold quality
tibial artery	UBERON:0007610	50.87	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.78

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• LINC01686 affects LPS-induced cytokine expression via the miR-18a-5p/A20/STAT1 axis in THP-1 cells. (PMID:38578001)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.