LINC01703

Summary

LINC01703 (long intergenic non-protein coding RNA 1703, HGNC:52491) is a long non-coding RNA gene on chromosome 1q42.12.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:52491
Approved symbol	LINC01703
Name	long intergenic non-protein coding RNA 1703
Location	1q42.12
Locus type	RNA, long non-coding
Status	Approved
Aliases	lncPARP1
Ensembl gene	ENSG00000225518
Ensembl biotype	lncRNA
Entrez	105373113
RNAcentral	URS0000BC460D — lncRNA, 882 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 8 — 8 lncRNA

ENST00000412855, ENST00000602806, ENST00000655338, ENST00000656201, ENST00000759912, ENST00000759913, ENST00000759914, ENST00000759915

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000412855 — 4 exons

Exon	Start	End
ENSE00001595900	226086882	226087053
ENSE00001739808	226090225	226090292
ENSE00003406284	226083951	226083968
ENSE00004113083	226089490	226089654

Expression profiles

Bgee: expression breadth ubiquitous, 155 present calls, max score 85.03.

Top tissues by expression

240 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	85.03	gold quality
buccal mucosa cell	CL:0002336	82.81	silver quality
colonic epithelium	UBERON:0000397	75.75	gold quality
stromal cell of endometrium	CL:0002255	69.68	gold quality
hindlimb stylopod muscle	UBERON:0004252	69.64	gold quality
sural nerve	UBERON:0015488	68.39	gold quality
tendon of biceps brachii	UBERON:0008188	68.15	gold quality
muscle of leg	UBERON:0001383	68.10	gold quality
skin of abdomen	UBERON:0001416	67.70	gold quality
gastrocnemius	UBERON:0001388	67.35	gold quality
skin of leg	UBERON:0001511	66.54	gold quality
body of pancreas	UBERON:0001150	66.36	gold quality
nucleus accumbens	UBERON:0001882	66.19	gold quality
left ovary	UBERON:0002119	65.38	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	65.33	gold quality
ganglionic eminence	UBERON:0004023	65.22	gold quality
caudate nucleus	UBERON:0001873	65.01	gold quality
zone of skin	UBERON:0000014	64.99	gold quality
ventricular zone	UBERON:0003053	64.73	gold quality
pancreas	UBERON:0001264	64.66	gold quality
endocervix	UBERON:0000458	64.54	gold quality
putamen	UBERON:0001874	64.54	gold quality
anterior cingulate cortex	UBERON:0009835	64.38	gold quality
cerebellar hemisphere	UBERON:0002245	64.15	gold quality
cerebellar cortex	UBERON:0002129	63.91	gold quality
hypothalamus	UBERON:0001898	63.85	gold quality
right ovary	UBERON:0002118	63.81	gold quality
prefrontal cortex	UBERON:0000451	63.78	gold quality
right hemisphere of cerebellum	UBERON:0014890	63.74	gold quality
minor salivary gland	UBERON:0001830	63.33	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	3.08

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• The long noncoding RNA lncPARP1 contributes to progression of hepatocellular carcinoma through up-regulation of PARP1. (PMID:29776974)
• Long Noncoding RNA LINC01703 Exacerbates the Malignant Properties of Non-Small Cell Lung Cancer by Upregulating MACC1 in a MicroRNA-605-3p-Mediated Manner. (PMID:34493358)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.