LINC01727

Summary

LINC01727 (long intergenic non-protein coding RNA 1727, HGNC:52515) is a long non-coding RNA gene on chromosome 20p11.22.

Predicted to act upstream of or within positive regulation of gene expression and positive regulation of oligodendrocyte differentiation. Predicted to be located in cytoplasm.

Source: NCBI Gene 101929625 — RefSeq curated summary.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:52515
Approved symbol	LINC01727
Name	long intergenic non-protein coding RNA 1727
Location	20p11.22
Locus type	RNA, long non-coding
Status	Approved
Aliases	IRENA
Ensembl gene	ENSG00000279082
Ensembl biotype	lncRNA
Entrez	101929625
RNAcentral	URS000075DA7F — lncRNA, 567 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 55 — 55 lncRNA

ENST00000622928, ENST00000623256, ENST00000624367, ENST00000624385, ENST00000653224, ENST00000653966, ENST00000654700, ENST00000655015, ENST00000655574, ENST00000659009, ENST00000661947, ENST00000663538, ENST00000665084, ENST00000666232, ENST00000668557, ENST00000668638, ENST00000668797, ENST00000669771, ENST00000685162, ENST00000687963, ENST00000688170, ENST00000689133, ENST00000690359, ENST00000691139, ENST00000749957, ENST00000749959, ENST00000749960, ENST00000749961, ENST00000749962, ENST00000749963, ENST00000749964, ENST00000749965, ENST00000749966, ENST00000749967, ENST00000749968, ENST00000749969, ENST00000749970, ENST00000749971, ENST00000749972, ENST00000749973, ENST00000749974, ENST00000749975, ENST00000749976, ENST00000749977, ENST00000749978, ENST00000749979, ENST00000749980, ENST00000749981, ENST00000749982, ENST00000749983, ENST00000749984, ENST00000749985, ENST00000749986, ENST00000749987, ENST00000749988

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000622928 — 2 exons

Exon	Start	End
ENSE00003981040	21577595	21578028
ENSE00004093955	21569853	21570248

Expression profiles

Bgee: expression breadth ubiquitous, 118 present calls, max score 78.61.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.1764 / max 37.3629, expressed in 44 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
183804	0.1764	44

Top tissues by expression

118 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	78.61	gold quality
right hemisphere of cerebellum	UBERON:0014890	77.19	gold quality
cerebellum	UBERON:0002037	75.28	gold quality
cerebellar cortex	UBERON:0002129	75.23	gold quality
cerebellar hemisphere	UBERON:0002245	75.06	gold quality
liver	UBERON:0002107	71.03	gold quality
right frontal lobe	UBERON:0002810	70.12	gold quality
anterior cingulate cortex	UBERON:0009835	69.21	gold quality
right lobe of liver	UBERON:0001114	69.03	gold quality
primary visual cortex	UBERON:0002436	68.89	gold quality
frontal cortex	UBERON:0001870	68.59	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	68.52	gold quality
superior frontal gyrus	UBERON:0002661	67.89	gold quality
Brodmann (1909) area 9	UBERON:0013540	67.67	gold quality
prefrontal cortex	UBERON:0000451	67.50	gold quality
cerebral cortex	UBERON:0000956	65.89	gold quality
cortex of kidney	UBERON:0001225	65.88	gold quality
sural nerve	UBERON:0015488	64.65	silver quality
lymph node	UBERON:0000029	62.38	gold quality
brain	UBERON:0000955	61.79	gold quality
hindlimb stylopod muscle	UBERON:0004252	61.56	gold quality
nucleus accumbens	UBERON:0001882	61.55	gold quality
skeletal muscle tissue	UBERON:0001134	61.08	gold quality
tonsil	UBERON:0002372	60.72	gold quality
corpus callosum	UBERON:0002336	59.82	gold quality
ventricular zone	UBERON:0003053	59.49	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	59.21	gold quality
ganglionic eminence	UBERON:0004023	59.09	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	55.84	gold quality
kidney	UBERON:0002113	55.18	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	3.08

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.