LINC01748

Summary

LINC01748 (long intergenic non-protein coding RNA 1748, HGNC:52535) is a long non-coding RNA gene on chromosome 1p32.1.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:52535
Approved symbol	LINC01748
Name	long intergenic non-protein coding RNA 1748
Location	1p32.1
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000226476
Ensembl biotype	lncRNA
Entrez	105378763
RNAcentral	URS00009C60F6 — lncRNA, 3229 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 38 — 38 lncRNA

ENST00000439156, ENST00000634281, ENST00000634836, ENST00000635048, ENST00000635616, ENST00000654255, ENST00000654935, ENST00000656757, ENST00000657534, ENST00000660110, ENST00000660992, ENST00000661045, ENST00000661176, ENST00000661790, ENST00000662037, ENST00000662065, ENST00000662596, ENST00000663215, ENST00000665573, ENST00000666208, ENST00000668078, ENST00000668738, ENST00000668888, ENST00000670448, ENST00000671019, ENST00000671035, ENST00000673767, ENST00000686091, ENST00000827529, ENST00000827530, ENST00000827531, ENST00000827532, ENST00000827533, ENST00000827534, ENST00000827535, ENST00000827536, ENST00000827537, ENST00000827538

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000439156 — 8 exons

Exon	Start	End
ENSE00001604800	60588037	60588162
ENSE00001614456	60540249	60540433
ENSE00001675738	60573338	60573413
ENSE00001722886	60640011	60640126
ENSE00001745060	60595538	60596373
ENSE00001781545	60600127	60600250
ENSE00001799754	60542297	60542411
ENSE00001805953	60640272	60640491

Expression profiles

Bgee: expression breadth ubiquitous, 125 present calls, max score 79.33.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.0457 / max 14.3536, expressed in 22 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
12594	0.0457	22

Top tissues by expression

125 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	79.33	silver quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	77.58	gold quality
ganglionic eminence	UBERON:0004023	73.15	gold quality
caudate nucleus	UBERON:0001873	72.47	gold quality
corpus callosum	UBERON:0002336	72.37	gold quality
nucleus accumbens	UBERON:0001882	71.96	gold quality
prostate gland	UBERON:0002367	71.57	gold quality
putamen	UBERON:0001874	71.11	gold quality
ventricular zone	UBERON:0003053	69.66	gold quality
superior frontal gyrus	UBERON:0002661	67.80	gold quality
Brodmann (1909) area 9	UBERON:0013540	67.17	gold quality
spleen	UBERON:0002106	67.09	gold quality
primary visual cortex	UBERON:0002436	66.67	gold quality
amygdala	UBERON:0001876	66.26	gold quality
temporal lobe	UBERON:0001871	66.22	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	66.06	gold quality
vagina	UBERON:0000996	65.64	gold quality
anterior cingulate cortex	UBERON:0009835	65.55	gold quality
sural nerve	UBERON:0015488	65.45	gold quality
prefrontal cortex	UBERON:0000451	65.25	gold quality
frontal cortex	UBERON:0001870	65.09	gold quality
cerebral cortex	UBERON:0000956	64.89	gold quality
cortical plate	UBERON:0005343	64.52	gold quality
right frontal lobe	UBERON:0002810	64.49	gold quality
placenta	UBERON:0001987	63.21	gold quality
brain	UBERON:0000955	63.19	gold quality
mucosa of transverse colon	UBERON:0004991	62.66	gold quality
esophagus mucosa	UBERON:0002469	62.46	gold quality
hindlimb stylopod muscle	UBERON:0004252	61.98	gold quality
skeletal muscle tissue	UBERON:0001134	61.51	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	6.32

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Long noncoding RNA LINC01748 exerts carcinogenic effects in nonsmall cell lung cancer cell lines by regulating the microRNA520a5p/HMGA1 axis. (PMID:34970695)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.