LINC01857

Summary

LINC01857 (long intergenic non-protein coding RNA 1857, HGNC:52673) is a long non-coding RNA gene on chromosome 2q33.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:52673
Approved symbol	LINC01857
Name	long intergenic non-protein coding RNA 1857
Location	2q33.3
Locus type	RNA, long non-coding
Status	Approved
Aliases	AC079767.4
Ensembl gene	ENSG00000224137
Ensembl biotype	lncRNA
Entrez	102724714
RNAcentral	URS0000A76B57 — lncRNA, 437 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 5 — 5 lncRNA

ENST00000429730, ENST00000691648, ENST00000754137, ENST00000754138, ENST00000754139

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000429730 — 2 exons

Exon	Start	End
ENSE00004101927	207666681	207667450
ENSE00004101930	207662371	207662522

Expression profiles

Bgee: expression breadth ubiquitous, 132 present calls, max score 90.54.

FANTOM5 (CAGE): breadth broad, TPM avg 5.0476 / max 587.2410, expressed in 262 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
24890	4.4716	252
24891	0.4580	122
24892	0.1181	64

Top tissues by expression

224 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
spleen	UBERON:0002106	90.54	gold quality
lymph node	UBERON:0000029	88.87	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	88.55	gold quality
ileal mucosa	UBERON:0000331	85.94	gold quality
granulocyte	CL:0000094	81.23	gold quality
vermiform appendix	UBERON:0001154	81.10	gold quality
tonsil	UBERON:0002372	75.58	gold quality
bone marrow cell	CL:0002092	72.97	silver quality
caecum	UBERON:0001153	72.37	gold quality
blood	UBERON:0000178	68.60	gold quality
small intestine Peyer’s patch	UBERON:0003454	67.89	gold quality
tibialis anterior	UBERON:0001385	67.76	silver quality
colonic epithelium	UBERON:0000397	67.56	gold quality
gall bladder	UBERON:0002110	67.31	gold quality
small intestine	UBERON:0002108	64.75	gold quality
leukocyte	CL:0000738	64.69	gold quality
hindlimb stylopod muscle	UBERON:0004252	64.60	gold quality
rectum	UBERON:0001052	64.48	gold quality
epithelium of nasopharynx	UBERON:0001951	63.56	gold quality
monocyte	CL:0000576	62.81	gold quality
pancreatic ductal cell	CL:0002079	61.92	silver quality
mucosa of transverse colon	UBERON:0004991	59.36	gold quality
islet of Langerhans	UBERON:0000006	57.61	gold quality
anterior cingulate cortex	UBERON:0009835	57.44	gold quality
right lung	UBERON:0002167	56.59	gold quality
smooth muscle tissue	UBERON:0001135	56.12	gold quality
upper lobe of left lung	UBERON:0008952	55.02	gold quality
epithelial cell of pancreas	CL:0000083	54.88	gold quality
left coronary artery	UBERON:0001626	54.71	gold quality
upper leg skin	UBERON:0004262	54.61	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	7.87

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 5)

• our findings demonstrated that LINC01857 promoted breast cancer development by promoting H3K27Ac and CREB1 transcription via enhancing CREBBP enrichment in the CREB1 promoter region. (PMID:30628071)
• this study first demonstrated that a novel LINC01857/miR-1281/TRIM65 signaling regulates glioma progression (PMID:31049960)
• LINC01857 promotes the development of gastric cancer by regulating microRNA-200b. (PMID:32329840)
• Role of long intergenic non-protein coding RNA 01857 in hepatocellular carcinoma malignancy via the regulation of the microRNA-197-3p/anterior GRadient 2 axis. (PMID:34793477)
• LINC01857 promotes the proliferation, migration, and invasion of gastric cancer cells via regulating miR-4731-5p/HOXC6. (PMID:35468304)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.