LINC01963

Summary

LINC01963 (long intergenic non-protein coding RNA 1963, HGNC:25283) is a long non-coding RNA gene on chromosome 2q35.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:25283
Approved symbol	LINC01963
Name	long intergenic non-protein coding RNA 1963
Location	2q35
Locus type	RNA, long non-coding
Status	Approved
Aliases	DKFZp434H1419
Ensembl gene	ENSG00000260804
Ensembl biotype	lncRNA
Entrez	150967
RNAcentral	URS000075B935 — lncRNA, 3353 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 2 — 2 lncRNA

ENST00000562038, ENST00000787976

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000562038 — 1 exons

Exon	Start	End
ENSE00002618694	216217045	216220192

Expression profiles

Bgee: expression breadth ubiquitous, 228 present calls, max score 93.58.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.2156 / max 76.6709, expressed in 36 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
25208	0.2156	36

Top tissues by expression

285 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
Brodmann (1909) area 10	UBERON:0013541	93.58	gold quality
frontal pole	UBERON:0002795	93.19	gold quality
cortical plate	UBERON:0005343	91.51	gold quality
paraflocculus	UBERON:0005351	90.12	gold quality
middle frontal gyrus	UBERON:0002702	89.95	gold quality
right frontal lobe	UBERON:0002810	89.42	gold quality
ganglionic eminence	UBERON:0004023	89.36	gold quality
Brodmann (1909) area 9	UBERON:0013540	89.12	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	89.01	gold quality
cerebellar cortex	UBERON:0002129	88.51	gold quality
cerebellar hemisphere	UBERON:0002245	88.44	gold quality
right hemisphere of cerebellum	UBERON:0014890	88.34	gold quality
cingulate cortex	UBERON:0003027	88.23	gold quality
anterior cingulate cortex	UBERON:0009835	88.20	gold quality
frontal cortex	UBERON:0001870	88.19	gold quality
prefrontal cortex	UBERON:0000451	88.09	gold quality
neocortex	UBERON:0001950	87.98	gold quality
cerebellum	UBERON:0002037	87.89	gold quality
cerebellar vermis	UBERON:0004720	87.49	gold quality
nucleus accumbens	UBERON:0001882	87.34	gold quality
cerebral cortex	UBERON:0000956	86.77	gold quality
telencephalon	UBERON:0001893	86.10	gold quality
caudate nucleus	UBERON:0001873	86.04	gold quality
superior frontal gyrus	UBERON:0002661	85.42	gold quality
brain	UBERON:0000955	85.16	gold quality
putamen	UBERON:0001874	85.14	gold quality
forebrain	UBERON:0001890	85.06	gold quality
central nervous system	UBERON:0001017	84.95	gold quality
lateral nuclear group of thalamus	UBERON:0002736	84.61	gold quality
orbitofrontal cortex	UBERON:0004167	84.59	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.49

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• the interaction of GAGA transcription factors with Box 1 and Box 2 could regulate the transcription of the PKI55 gene and, consequently, the expression of PKC. (PMID:19095038)
• Long non-coding RNA LINC01963 inhibits progression of pancreatic carcinoma by targeting miR-641/TMEFF2. (PMID:32559621)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.