LINC01977

Summary

LINC01977 (long intergenic non-protein coding RNA 1977, HGNC:52804) is a long non-coding RNA gene on chromosome 17q25.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:52804
Approved symbol	LINC01977
Name	long intergenic non-protein coding RNA 1977
Location	17q25.3
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000262772
Ensembl biotype	lncRNA
Entrez	105371919
RNAcentral	URS0000BC44EE — lncRNA, 1799 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 15 — 15 lncRNA

ENST00000576963, ENST00000667764, ENST00000736266, ENST00000736267, ENST00000736268, ENST00000736269, ENST00000736270, ENST00000736271, ENST00000736272, ENST00000736273, ENST00000736274, ENST00000736275, ENST00000736276, ENST00000736277, ENST00000736278

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000576963 — 3 exons

Exon	Start	End
ENSE00002639791	79823795	79823874
ENSE00002659827	79826084	79827704
ENSE00003883558	79822634	79823538

Expression profiles

Bgee: expression breadth ubiquitous, 114 present calls, max score 76.17.

Top tissues by expression

216 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
bone marrow cell	CL:0002092	76.17	silver quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	75.29	gold quality
right testis	UBERON:0004534	73.76	gold quality
left testis	UBERON:0004533	69.43	gold quality
buccal mucosa cell	CL:0002336	69.35	gold quality
testis	UBERON:0000473	67.13	gold quality
adenohypophysis	UBERON:0002196	62.80	gold quality
pituitary gland	UBERON:0000007	62.02	gold quality
corpus epididymis	UBERON:0004359	60.64	gold quality
ganglionic eminence	UBERON:0004023	60.55	gold quality
ventricular zone	UBERON:0003053	60.16	gold quality
cortical plate	UBERON:0005343	59.35	gold quality
cardiac muscle of right atrium	UBERON:0003379	54.34	gold quality
left ventricle myocardium	UBERON:0006566	54.23	gold quality
right uterine tube	UBERON:0001302	54.04	gold quality
hindlimb stylopod muscle	UBERON:0004252	54.02	gold quality
kidney epithelium	UBERON:0004819	53.93	gold quality
right atrium auricular region	UBERON:0006631	53.80	gold quality
cardiac atrium	UBERON:0002081	53.65	gold quality
upper arm skin	UBERON:0004263	53.52	gold quality
cauda epididymis	UBERON:0004360	53.23	gold quality
monocyte	CL:0000576	53.17	silver quality
epithelial cell of pancreas	CL:0000083	52.91	gold quality
caput epididymis	UBERON:0004358	52.88	gold quality
apex of heart	UBERON:0002098	52.70	gold quality
tibialis anterior	UBERON:0001385	52.46	silver quality
minor salivary gland	UBERON:0001830	52.26	gold quality
sural nerve	UBERON:0015488	51.70	silver quality
lower esophagus mucosa	UBERON:0035834	51.43	gold quality
body of pancreas	UBERON:0001150	50.95	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.28

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Super-enhancer hijacking LINC01977 promotes malignancy of early-stage lung adenocarcinoma addicted to the canonical TGF-beta/SMAD3 pathway. (PMID:35982471)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.