LINC01980

Summary

LINC01980 (long intergenic non-protein coding RNA 1980, HGNC:52808) is a long non-coding RNA gene on chromosome 3p24.1.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:52808
Approved symbol	LINC01980
Name	long intergenic non-protein coding RNA 1980
Location	3p24.1
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000225548
Ensembl biotype	lncRNA
Entrez	105377007
RNAcentral	URS0000BC45DF — lncRNA, 813 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 55 — 55 lncRNA

ENST00000414382, ENST00000425195, ENST00000455984, ENST00000647336, ENST00000652951, ENST00000653125, ENST00000653311, ENST00000653500, ENST00000654194, ENST00000654315, ENST00000655422, ENST00000655661, ENST00000656964, ENST00000658403, ENST00000659724, ENST00000660141, ENST00000660687, ENST00000660818, ENST00000660828, ENST00000661836, ENST00000663074, ENST00000663087, ENST00000663111, ENST00000663406, ENST00000664737, ENST00000665057, ENST00000665634, ENST00000665786, ENST00000667173, ENST00000668400, ENST00000668561, ENST00000668591, ENST00000668917, ENST00000669211, ENST00000669343, ENST00000669745, ENST00000670767, ENST00000670769, ENST00000746453, ENST00000746454, ENST00000746455, ENST00000746456, ENST00000746457, ENST00000746458, ENST00000746459, ENST00000746460, ENST00000746461, ENST00000746462, ENST00000746463, ENST00000746464, ENST00000746465, ENST00000746466, ENST00000746467, ENST00000746468, ENST00000746469

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000414382 — 3 exons

Exon	Start	End
ENSE00001678224	27891095	27891301
ENSE00001706031	27821488	27821724
ENSE00001768818	27824650	27824748

Expression profiles

Bgee: expression breadth broad, 84 present calls, max score 87.27.

Top tissues by expression

84 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	87.27	gold quality
cortex of kidney	UBERON:0001225	79.57	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	78.62	gold quality
sural nerve	UBERON:0015488	72.03	gold quality
ganglionic eminence	UBERON:0004023	61.49	gold quality
right lobe of liver	UBERON:0001114	60.31	gold quality
liver	UBERON:0002107	59.94	gold quality
gall bladder	UBERON:0002110	58.19	gold quality
ventricular zone	UBERON:0003053	58.12	silver quality
prefrontal cortex	UBERON:0000451	56.93	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	56.17	gold quality
monocyte	CL:0000576	55.52	gold quality
placenta	UBERON:0001987	55.44	gold quality
saliva-secreting gland	UBERON:0001044	54.97	gold quality
blood	UBERON:0000178	53.81	gold quality
esophagus mucosa	UBERON:0002469	53.61	gold quality
minor salivary gland	UBERON:0001830	53.47	gold quality
vagina	UBERON:0000996	52.64	gold quality
lymph node	UBERON:0000029	52.56	gold quality
right atrium auricular region	UBERON:0006631	52.41	gold quality
adenohypophysis	UBERON:0002196	52.13	gold quality
pituitary gland	UBERON:0000007	51.75	gold quality
skin of abdomen	UBERON:0001416	51.33	gold quality
zone of skin	UBERON:0000014	50.30	gold quality
heart	UBERON:0000948	50.18	gold quality
muscle of leg	UBERON:0001383	49.88	gold quality
rectum	UBERON:0001052	49.68	gold quality
left adrenal gland	UBERON:0001234	49.62	gold quality
skin of leg	UBERON:0001511	49.54	gold quality
heart left ventricle	UBERON:0002084	49.44	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	3.21

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• LINC01980 is upregulated in human esophageal squamous cell carcinoma (ESCC) tissues and correlates with poor prognosis. LINC01980 promotes ESCC cells growth and proliferation in vitro and in vivo. LINC01980 accelerates cell cycle progression and prevents cell apoptosis. (PMID:30935686)
• LINC01980 induced by TGF-beta promotes hepatocellular carcinoma metastasis via miR-376b-5p/E2F5 axis. (PMID:37827344)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.