LINC02119

Summary

LINC02119 (long intergenic non-protein coding RNA 2119, HGNC:52975) is a long non-coding RNA gene on chromosome 5p13.2.

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:52975
Approved symbol	LINC02119
Name	long intergenic non-protein coding RNA 2119
Location	5p13.2
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000248461
Entrez	101929745
RNAcentral	URS0000A76C3F — lncRNA, 2590 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 0

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

None — 0 exons

Expression profiles

Bgee: expression breadth broad, 55 present calls, max score 78.77.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.0264 / max 9.0560, expressed in 6 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
56185	0.0195	4
56184	0.0069	4

Top tissues by expression

166 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	78.77	gold quality
hindlimb stylopod muscle	UBERON:0004252	71.74	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	66.73	gold quality
endothelial cell	CL:0000115	63.40	gold quality
muscle of leg	UBERON:0001383	59.07	gold quality
sural nerve	UBERON:0015488	58.87	silver quality
gastrocnemius	UBERON:0001388	57.51	gold quality
monocyte	CL:0000576	55.97	gold quality
cortex of kidney	UBERON:0001225	55.18	gold quality
upper leg skin	UBERON:0004262	53.45	gold quality
upper lobe of lung	UBERON:0008948	50.38	silver quality
lower lobe of lung	UBERON:0008949	50.08	silver quality
skeletal muscle tissue	UBERON:0001134	49.40	gold quality
testis	UBERON:0000473	48.54	gold quality
right testis	UBERON:0004534	48.36	gold quality
left testis	UBERON:0004533	47.88	gold quality
Brodmann (1909) area 9	UBERON:0013540	47.80	silver quality
islet of Langerhans	UBERON:0000006	47.41	silver quality
left adrenal gland cortex	UBERON:0035825	46.48	silver quality
pancreas	UBERON:0001264	45.54	silver quality
thoracic aorta	UBERON:0001515	45.29	silver quality
adult mammalian kidney	UBERON:0000082	44.80	gold quality
skin of hip	UBERON:0001554	44.44	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	44.25	silver quality
kidney	UBERON:0002113	43.94	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	43.70	silver quality
apex of heart	UBERON:0002098	43.67	silver quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	43.37	gold quality
right atrium auricular region	UBERON:0006631	43.35	gold quality
anatomical system	UBERON:0000467	43.28	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	3.28

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Protein identifiers

Canonical reviewed UniProt: None (reviewed: )

All UniProt accessions (0):

RefSeq proteins (0): (*=MANE)

Domains & families (InterPro)

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 0 (showing top):

GO Biological Process (0):

GO Molecular Function (0):

GO Cellular Component (0):

Protein interactions and networks

STRING

0 interactions, top by confidence (×1000):

IntAct

0 interactions, top by confidence:

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

0 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

0 predictions. Top by Δscore:

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000037803 (5:38149800 C>A,T), RS1000410531 (5:38149582 C>A,T), RS1000425793 (5:38153750 C>G,T), RS1000618301 (5:38148126 T>C), RS1001203680 (5:38150491 A>G), RS1001443638 (5:38151551 C>T), RS1001710429 (5:38148477 C>T), RS1002045946 (5:38149819 A>G), RS1002098113 (5:38149645 T>C), RS1003178561 (5:38153230 T>C), RS1003250370 (5:38153437 A>C), RS1003412036 (5:38147066 G>A,T), RS1003713897 (5:38151348 C>T), RS1003766412 (5:38151035 A>G), RS1004276222 (5:38153247 T>C)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 0 entries

CTD chemical–gene interactions

3 total (human), top 3 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
OTX015	decreases expression	1
mivebresib	decreases expression	1
Leflunomide	increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.