LINC02159

Summary

LINC02159 (long intergenic non-protein coding RNA 2159, HGNC:27749) is a long non-coding RNA gene on chromosome 5q34.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:27749
Approved symbol	LINC02159
Name	long intergenic non-protein coding RNA 2159
Location	5q34
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000253417
Ensembl biotype	lncRNA
Entrez	285629
RNAcentral	URS000075CBF5 — lncRNA, 2339 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 2 — 2 lncRNA

ENST00000518301, ENST00000518580

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000518301 — 3 exons

Exon	Start	End
ENSE00002096009	160938454	160938626
ENSE00002112906	160931781	160933633
ENSE00002113773	160935990	160936109

Expression profiles

Bgee: expression breadth broad, 58 present calls, max score 69.02.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.2729 / max 252.1765, expressed in 85 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
64656	0.2184	75
64655	0.0438	9
203778	0.0107	3

Top tissues by expression

58 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
gall bladder	UBERON:0002110	69.02	gold quality
islet of Langerhans	UBERON:0000006	60.65	gold quality
prefrontal cortex	UBERON:0000451	56.01	gold quality
pancreas	UBERON:0001264	55.29	gold quality
tonsil	UBERON:0002372	53.34	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	53.30	gold quality
liver	UBERON:0002107	51.86	silver quality
metanephros cortex	UBERON:0010533	51.26	gold quality
blood	UBERON:0000178	49.58	gold quality
urinary bladder	UBERON:0001255	48.82	silver quality
kidney	UBERON:0002113	48.70	gold quality
saliva-secreting gland	UBERON:0001044	48.42	gold quality
minor salivary gland	UBERON:0001830	48.21	gold quality
adult mammalian kidney	UBERON:0000082	48.05	gold quality
body of stomach	UBERON:0001161	47.94	gold quality
heart left ventricle	UBERON:0002084	47.35	silver quality
stomach	UBERON:0000945	47.25	gold quality
esophagus	UBERON:0001043	47.01	gold quality
esophagus mucosa	UBERON:0002469	46.90	gold quality
tibial nerve	UBERON:0001323	46.59	gold quality
right lobe of thyroid gland	UBERON:0001119	46.47	gold quality
multicellular organism	UBERON:0000468	46.18	gold quality
endometrium	UBERON:0001295	45.67	gold quality
body of pancreas	UBERON:0001150	45.56	silver quality
vermiform appendix	UBERON:0001154	44.67	silver quality
skin of abdomen	UBERON:0001416	44.61	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	44.60	gold quality
monocyte	CL:0000576	44.08	silver quality
thyroid gland	UBERON:0002046	43.40	gold quality
zone of skin	UBERON:0000014	43.37	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• LINC02159 promotes non-small cell lung cancer progression via ALYREF/YAP1 signaling. (PMID:37537569)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.