LINC02218

Summary

LINC02218 (long intergenic non-protein coding RNA 2218, HGNC:53085) is a protein-coding gene on chromosome 5p15.1.

Predicted to enable protein heterodimerization activity. Predicted to contribute to RNA polymerase II general transcription initiation factor activity. Predicted to be involved in RNA polymerase II preinitiation complex assembly. Predicted to be located in nucleus. Predicted to be part of transcription factor TFIID complex.

Source: NCBI Gene 102723526 — RefSeq curated summary.

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:53085
Approved symbol	LINC02218
Name	long intergenic non-protein coding RNA 2218
Location	5p15.1
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000249662
Ensembl biotype	protein_coding
Entrez	102723526
RNAcentral	URS0000556FCD — lncRNA, 582 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 2 — 1 protein_coding_CDS_not_defined, 1 protein_coding

ENST00000503267, ENST00000638486

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000503267 — 2 exons

Exon	Start	End
ENSE00002037755	17445627	17445930
ENSE00002039748	17444010	17444234

Expression profiles

Bgee: expression breadth broad, 44 present calls, max score 67.07.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.2359 / max 111.1733, expressed in 27 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
55888	0.2359	27

Top tissues by expression

229 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
tibialis anterior	UBERON:0001385	67.07	silver quality
pancreatic ductal cell	CL:0002079	63.36	silver quality
blood	UBERON:0000178	62.90	gold quality
leukocyte	CL:0000738	61.47	gold quality
ileal mucosa	UBERON:0000331	61.30	silver quality
monocyte	CL:0000576	60.77	gold quality
buccal mucosa cell	CL:0002336	58.64	gold quality
granulocyte	CL:0000094	55.24	gold quality
epithelial cell of pancreas	CL:0000083	55.06	gold quality
cardiac muscle of right atrium	UBERON:0003379	54.34	gold quality
left ventricle myocardium	UBERON:0006566	54.23	gold quality
kidney epithelium	UBERON:0004819	53.93	gold quality
upper arm skin	UBERON:0004263	53.52	gold quality
deltoid	UBERON:0001476	52.34	gold quality
myocardium	UBERON:0002349	50.25	gold quality
quadriceps femoris	UBERON:0001377	47.37	gold quality
nasal cavity epithelium	UBERON:0005384	47.03	gold quality
prefrontal cortex	UBERON:0000451	46.52	gold quality
vastus lateralis	UBERON:0001379	45.40	gold quality
frontal cortex	UBERON:0001870	44.67	gold quality
middle temporal gyrus	UBERON:0002771	44.22	gold quality
synovial joint	UBERON:0002217	44.05	gold quality
neocortex	UBERON:0001950	43.75	gold quality
layer of synovial tissue	UBERON:0007616	43.55	gold quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	43.37	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	43.09	gold quality
right frontal lobe	UBERON:0002810	43.01	gold quality
secondary oocyte	CL:0000655	42.57	gold quality
bone marrow	UBERON:0002371	42.57	silver quality
superior frontal gyrus	UBERON:0002661	42.56	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	2.63
E-HCAD-30	no	76.80

Regulation

Is transcription factor: no

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
danio_rerio	taf11	ENSDARG00000037855
drosophila_melanogaster	Taf11	FBGN0011291
caenorhabditis_elegans		WBGENE00006393
caenorhabditis_elegans	taf-11.2	WBGENE00006394

Paralogs (14): TAF11 (ENSG00000064995), TAF11L12 (ENSG00000249156), TAF11L14 (ENSG00000250782), TAF11L11 (ENSG00000283740), TAF11L13 (ENSG00000283776), TAF11L8 (ENSG00000283967), TAF11L9 (ENSG00000283988), TAF11L6 (ENSG00000284042), TAF11L5 (ENSG00000284234), TAF11L4 (ENSG00000284283), TAF11L10 (ENSG00000284356), TAF11L2 (ENSG00000284373), TAF11L3 (ENSG00000284439), TAF11L7 (ENSG00000284465)

Protein

Protein identifiers

Canonical reviewed UniProt: None (reviewed: )

All UniProt accessions (1): A0A1W2PRN6

RefSeq proteins (0): (*=MANE)

Domains & families (InterPro)

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 4 (showing top): CHAF1B_TARGET_GENES, ZNF274_TARGET_GENES, EWSR1_TARGET_GENES, chr5p15

GO Biological Process (2): transcription initiation at RNA polymerase II promoter (GO:0006367), RNA polymerase II preinitiation complex assembly (GO:0051123)

GO Molecular Function (2): RNA polymerase II general transcription initiation factor activity (GO:0016251), protein heterodimerization activity (GO:0046982)

GO Cellular Component (2): nucleus (GO:0005634), transcription factor TFIID complex (GO:0005669)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transcription by RNA polymerase II	2
DNA-templated transcription initiation	1
transcription initiation at RNA polymerase II promoter	1
transcription preinitiation complex assembly	1
general transcription initiation factor activity	1
protein dimerization activity	1
intracellular membrane-bounded organelle	1
RNA polymerase II, holoenzyme	1
RNA polymerase II transcription regulator complex	1

Protein interactions and networks

STRING

0 interactions, top by confidence (×1000):

IntAct

0 interactions, top by confidence:

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

0 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

0 predictions. Top by Δscore:

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000052133 (5:17455566 C>T), RS1000069964 (5:17460869 T>C), RS1000156283 (5:17464677 A>G), RS1000180653 (5:17446176 G>C), RS1000221647 (5:17452835 T>C), RS1000489635 (5:17458663 A>T), RS1000656049 (5:17464138 G>A,C), RS1000687566 (5:17482642 A>G), RS1000705149 (5:17475829 A>C), RS1000719174 (5:17453189 G>A), RS1000735504 (5:17452928 T>C), RS1000739470 (5:17482315 AT>A), RS1000763262 (5:17469722 G>A,C,T), RS1000900337 (5:17481524 G>A,T), RS1001001709 (5:17447933 G>A,T)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 0 entries

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.