LINC02220

Summary

LINC02220 (long intergenic non-protein coding RNA 2220, HGNC:53087) is a long non-coding RNA gene on chromosome 5p15.2.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:53087
Approved symbol	LINC02220
Name	long intergenic non-protein coding RNA 2220
Location	5p15.2
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000248457
Ensembl biotype	lncRNA
Entrez	105374658
RNAcentral	URS0000BC4653 — lncRNA, 527 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 3 — 3 lncRNA

ENST00000510065, ENST00000740130, ENST00000740131

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000510065 — 3 exons

Exon	Start	End
ENSE00002022414	13032786	13032886
ENSE00002036593	12914068	12914171
ENSE00002043850	13032011	13032075

Expression profiles

Bgee: expression breadth broad, 39 present calls, max score 81.80.

Top tissues by expression

39 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	81.80	silver quality
intestine	UBERON:0000160	70.53	gold quality
monocyte	CL:0000576	69.02	gold quality
prefrontal cortex	UBERON:0000451	68.88	gold quality
adult mammalian kidney	UBERON:0000082	61.56	gold quality
placenta	UBERON:0001987	61.28	gold quality
gastrocnemius	UBERON:0001388	61.19	gold quality
right testis	UBERON:0004534	59.50	gold quality
nucleus accumbens	UBERON:0001882	59.37	gold quality
kidney	UBERON:0002113	59.33	gold quality
right lobe of liver	UBERON:0001114	58.73	gold quality
superior frontal gyrus	UBERON:0002661	58.35	gold quality
stomach	UBERON:0000945	58.24	gold quality
left ovary	UBERON:0002119	57.79	gold quality
testis	UBERON:0000473	57.68	gold quality
corpus callosum	UBERON:0002336	57.45	gold quality
left testis	UBERON:0004533	57.01	gold quality
multicellular organism	UBERON:0000468	56.59	gold quality
fallopian tube	UBERON:0003889	56.51	gold quality
right frontal lobe	UBERON:0002810	56.15	gold quality
left lobe of thyroid gland	UBERON:0001120	55.79	gold quality
blood	UBERON:0000178	53.45	gold quality
adipose tissue	UBERON:0001013	52.84	gold quality
omental fat pad	UBERON:0010414	52.34	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	52.20	gold quality
Ammon’s horn	UBERON:0001954	51.58	gold quality
right adrenal gland	UBERON:0001233	51.18	gold quality
calcaneal tendon	UBERON:0003701	50.79	silver quality
anterior cingulate cortex	UBERON:0009835	49.97	gold quality
metanephros cortex	UBERON:0010533	49.86	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.64

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• DNAH5 gene and its correlation with linc02220 expression and sperm characteristics. (PMID:35960414)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.