LINC02221

Summary

LINC02221 (long intergenic non-protein coding RNA 2221, HGNC:53090) is a long non-coding RNA gene on chromosome 5p15.31.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:53090
Approved symbol	LINC02221
Name	long intergenic non-protein coding RNA 2221
Location	5p15.31
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000250814
Ensembl biotype	lncRNA
Entrez	105374648
RNAcentral	URS0000BC452F — lncRNA, 403 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 8 — 8 lncRNA

ENST00000508097, ENST00000650908, ENST00000654793, ENST00000661300, ENST00000746215, ENST00000746216, ENST00000746217, ENST00000746218

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000508097 — 2 exons

Exon	Start	End
ENSE00002055877	9889610	9889937
ENSE00002079069	9854377	9854547

Expression profiles

Bgee: expression breadth broad, 39 present calls, max score 87.39.

Top tissues by expression

175 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sperm	CL:0000019	87.39	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	86.19	gold quality
buccal mucosa cell	CL:0002336	77.05	silver quality
sural nerve	UBERON:0015488	74.71	gold quality
left testis	UBERON:0004533	58.31	gold quality
testis	UBERON:0000473	57.23	gold quality
right testis	UBERON:0004534	55.83	gold quality
cardiac muscle of right atrium	UBERON:0003379	54.84	gold quality
tibialis anterior	UBERON:0001385	54.60	silver quality
left ventricle myocardium	UBERON:0006566	54.23	gold quality
kidney epithelium	UBERON:0004819	53.93	gold quality
tibial nerve	UBERON:0001323	53.91	gold quality
epithelial cell of pancreas	CL:0000083	53.72	gold quality
upper arm skin	UBERON:0004263	53.52	gold quality
islet of Langerhans	UBERON:0000006	53.36	gold quality
upper lobe of lung	UBERON:0008948	53.22	silver quality
lower lobe of lung	UBERON:0008949	52.96	silver quality
pancreatic ductal cell	CL:0002079	52.32	silver quality
deltoid	UBERON:0001476	51.93	gold quality
monocyte	CL:0000576	50.96	silver quality
right lobe of liver	UBERON:0001114	50.52	silver quality
myocardium	UBERON:0002349	50.46	gold quality
skin of leg	UBERON:0001511	48.18	gold quality
gastrocnemius	UBERON:0001388	47.75	silver quality
nasal cavity epithelium	UBERON:0005384	47.44	gold quality
pancreas	UBERON:0001264	46.99	gold quality
quadriceps femoris	UBERON:0001377	46.46	gold quality
metanephros	UBERON:0000081	46.07	gold quality
skeletal muscle tissue	UBERON:0001134	46.06	gold quality
layer of synovial tissue	UBERON:0007616	45.55	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	2.61

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.