LINC02223

Summary

LINC02223 (long intergenic non-protein coding RNA 2223, HGNC:53092) is a long non-coding RNA gene on chromosome 5p15.1.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:53092
Approved symbol	LINC02223
Name	long intergenic non-protein coding RNA 2223
Location	5p15.1
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000249937
Ensembl biotype	lncRNA
Entrez	646241
RNAcentral	URS0000A763B7 — lncRNA, 1954 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 73 — 73 lncRNA

ENST00000510648, ENST00000511596, ENST00000514771, ENST00000648234, ENST00000650405, ENST00000652301, ENST00000652872, ENST00000653777, ENST00000654406, ENST00000655908, ENST00000657374, ENST00000658985, ENST00000661046, ENST00000662053, ENST00000662878, ENST00000665296, ENST00000665617, ENST00000668703, ENST00000670782, ENST00000687269, ENST00000726135, ENST00000726136, ENST00000726137, ENST00000726138, ENST00000726139, ENST00000726140, ENST00000726141, ENST00000726142, ENST00000726143, ENST00000726144, ENST00000726145, ENST00000726146, ENST00000726147, ENST00000726148, ENST00000726149, ENST00000726150, ENST00000726151, ENST00000726152, ENST00000726153, ENST00000726154, ENST00000726155, ENST00000726156, ENST00000726157, ENST00000726158, ENST00000726159, ENST00000726160, ENST00000726161, ENST00000726162, ENST00000726163, ENST00000726164, ENST00000726165, ENST00000726166, ENST00000726167, ENST00000726168, ENST00000726169, ENST00000726170, ENST00000726171, ENST00000726172, ENST00000726173, ENST00000726174, ENST00000726175, ENST00000726176, ENST00000726177, ENST00000726178, ENST00000726179, ENST00000726180, ENST00000726181, ENST00000726182, ENST00000726183, ENST00000726184, ENST00000726185, ENST00000790439, ENST00000790440

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000510648 — 4 exons

Exon	Start	End
ENSE00002019737	17926824	17926959
ENSE00002044972	17955694	17955837
ENSE00002073584	17920227	17920309
ENSE00004050426	17919023	17919323

Expression profiles

Bgee: expression breadth ubiquitous, 143 present calls, max score 82.12.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.0837 / max 13.2846, expressed in 38 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
55892	0.0575	29
55891	0.0262	7

Top tissues by expression

231 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	82.12	silver quality
hypothalamus	UBERON:0001898	72.76	gold quality
Brodmann (1909) area 9	UBERON:0013540	71.24	gold quality
anterior cingulate cortex	UBERON:0009835	70.40	gold quality
amygdala	UBERON:0001876	70.26	gold quality
right frontal lobe	UBERON:0002810	69.74	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	68.98	gold quality
prefrontal cortex	UBERON:0000451	67.17	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	67.02	gold quality
secondary oocyte	CL:0000655	66.02	silver quality
putamen	UBERON:0001874	65.21	gold quality
oocyte	CL:0000023	65.07	silver quality
neocortex	UBERON:0001950	64.12	gold quality
nucleus accumbens	UBERON:0001882	63.82	gold quality
ganglionic eminence	UBERON:0004023	63.54	gold quality
caudate nucleus	UBERON:0001873	63.26	gold quality
frontal cortex	UBERON:0001870	63.18	gold quality
Ammon’s horn	UBERON:0001954	63.13	gold quality
cerebellar hemisphere	UBERON:0002245	63.09	gold quality
cerebellar cortex	UBERON:0002129	63.05	gold quality
cerebral cortex	UBERON:0000956	62.66	gold quality
forebrain	UBERON:0001890	61.97	gold quality
cerebellum	UBERON:0002037	61.50	gold quality
brain	UBERON:0000955	61.33	gold quality
right hemisphere of cerebellum	UBERON:0014890	61.32	gold quality
ventricular zone	UBERON:0003053	61.08	gold quality
smooth muscle tissue	UBERON:0001135	60.40	gold quality
monocyte	CL:0000576	60.18	gold quality
pigmented layer of retina	UBERON:0001782	59.62	silver quality
substantia nigra	UBERON:0002038	58.32	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	5.38

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.