LINC02227

Summary

LINC02227 (long intergenic non-protein coding RNA 2227, HGNC:53096) is a long non-coding RNA gene on chromosome 5q33.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:53096
Approved symbol	LINC02227
Name	long intergenic non-protein coding RNA 2227
Location	5q33.3
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000276778
Ensembl biotype	lncRNA
Entrez	101927697
RNAcentral	URS000075B963 — lncRNA, 3748 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 17 — 17 lncRNA

ENST00000619068, ENST00000809484, ENST00000809485, ENST00000809486, ENST00000809487, ENST00000809488, ENST00000809489, ENST00000809490, ENST00000809491, ENST00000809492, ENST00000809493, ENST00000809494, ENST00000809495, ENST00000809496, ENST00000809497, ENST00000809498, ENST00000809499

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000619068 — 7 exons

Exon	Start	End
ENSE00003718361	158362402	158362541
ENSE00003721983	158369287	158369388
ENSE00003725563	158326060	158326204
ENSE00003730726	158341221	158341424
ENSE00003737716	158369535	158369610
ENSE00003752677	158320683	158323635
ENSE00003754362	158409646	158409773

Expression profiles

Bgee: expression breadth broad, 27 present calls, max score 81.51.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.1013 / max 38.4038, expressed in 24 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
64555	0.0892	23
64554	0.0121	6

Top tissues by expression

27 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
pancreas	UBERON:0001264	81.51	gold quality
blood	UBERON:0000178	57.32	silver quality
brain	UBERON:0000955	56.05	silver quality
lymph node	UBERON:0000029	50.47	gold quality
subcutaneous adipose tissue	UBERON:0002190	48.85	gold quality
multicellular organism	UBERON:0000468	48.30	gold quality
adipose tissue	UBERON:0001013	47.79	gold quality
duodenum	UBERON:0002114	47.50	silver quality
thoracic mammary gland	UBERON:0005200	47.13	gold quality
tonsil	UBERON:0002372	45.89	gold quality
left coronary artery	UBERON:0001626	45.52	gold quality
vermiform appendix	UBERON:0001154	45.10	silver quality
skin of abdomen	UBERON:0001416	44.32	gold quality
omental fat pad	UBERON:0010414	43.67	gold quality
gastrocnemius	UBERON:0001388	42.79	silver quality
transverse colon	UBERON:0001157	42.69	silver quality
colon	UBERON:0001155	40.55	silver quality
spleen	UBERON:0002106	40.30	silver quality
ascending aorta	UBERON:0001496	40.24	silver quality
tibial artery	UBERON:0007610	39.86	silver quality
body of stomach	UBERON:0001161	39.74	silver quality
stomach	UBERON:0000945	39.37	silver quality
tibial nerve	UBERON:0001323	38.39	silver quality
minor salivary gland	UBERON:0001830	37.43	silver quality
skin of leg	UBERON:0001511	37.33	silver quality
small intestine Peyer’s patch	UBERON:0003454	35.49	silver quality
left adrenal gland	UBERON:0001234	35.37	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	4.09

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.